Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2405905..2406467 Replicon chromosome
Accession NZ_CP099871
Organism Escherichia albertii strain 253_2_EW_B

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag NIZ24_RS11775 Protein ID WP_000605679.1
Coordinates 2405905..2406183 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIZ24_RS11780 Protein ID WP_000781369.1
Coordinates 2406183..2406467 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ24_RS11755 (2401885) 2401885..2402316 - 432 WP_059225291.1 peroxiredoxin OsmC -
NIZ24_RS11760 (2402583) 2402583..2402720 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIZ24_RS11765 (2402877) 2402877..2404574 + 1698 WP_000433442.1 malate dehydrogenase -
NIZ24_RS11770 (2404709) 2404709..2405719 + 1011 WP_000642386.1 alcohol dehydrogenase AdhP -
NIZ24_RS11775 (2405905) 2405905..2406183 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ24_RS11780 (2406183) 2406183..2406467 + 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIZ24_RS11785 (2406695) 2406695..2407348 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
NIZ24_RS11790 (2407341) 2407341..2408225 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
NIZ24_RS11795 (2408238) 2408238..2411285 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T249576 WP_000605679.1 NZ_CP099871:2405905-2406183 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249576 WP_000781369.1 NZ_CP099871:2406183-2406467 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure

References