Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 595977..596776 Replicon chromosome
Accession NZ_CP099871
Organism Escherichia albertii strain 253_2_EW_B

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag NIZ24_RS02940 Protein ID WP_000347251.1
Coordinates 595977..596441 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag NIZ24_RS02945 Protein ID WP_059250714.1
Coordinates 596441..596776 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ24_RS02910 (590978) 590978..591412 - 435 WP_044709898.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NIZ24_RS02915 (591430) 591430..592308 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NIZ24_RS02920 (592298) 592298..593077 - 780 WP_097755477.1 PTS N-acetylgalactosamine transporter subunit IIC -
NIZ24_RS02925 (593088) 593088..593561 - 474 WP_001132991.1 PTS N-acetylgalactosamine transporter subunit IIB -
NIZ24_RS02930 (593584) 593584..594864 - 1281 WP_059216469.1 tagatose-bisphosphate aldolase subunit KbaZ -
NIZ24_RS02935 (595113) 595113..595922 + 810 WP_059250716.1 aga operon transcriptional regulator AgaR -
NIZ24_RS02940 (595977) 595977..596441 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NIZ24_RS02945 (596441) 596441..596776 - 336 WP_059250714.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NIZ24_RS02950 (596925) 596925..598496 - 1572 WP_025238276.1 galactarate dehydratase -
NIZ24_RS02955 (598867) 598867..600201 + 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
NIZ24_RS02960 (600217) 600217..600987 + 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T249568 WP_000347251.1 NZ_CP099871:c596441-595977 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12335.94 Da        Isoelectric Point: 4.5392

>AT249568 WP_059250714.1 NZ_CP099871:c596776-596441 [Escherichia albertii]
MPANARSNAVLTTESKITIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure

References