Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3709996..3710646 Replicon chromosome
Accession NZ_CP099868
Organism Escherichia albertii strain 254_1_EW_B

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIZ25_RS18115 Protein ID WP_059224977.1
Coordinates 3710305..3710646 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag NIZ25_RS18110 Protein ID WP_025237546.1
Coordinates 3709996..3710295 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ25_RS18080 (3705126) 3705126..3705437 - 312 WP_059224980.1 hypothetical protein -
NIZ25_RS18085 (3705442) 3705442..3705834 - 393 WP_000273381.1 flagellar export chaperone FliS -
NIZ25_RS18090 (3705857) 3705857..3707173 - 1317 WP_000609691.1 flagellar filament capping protein FliD -
NIZ25_RS18095 (3707240) 3707240..3707575 - 336 WP_256876143.1 hypothetical protein -
NIZ25_RS18100 (3707686) 3707686..3708600 - 915 WP_000949079.1 lateral flagellin LafA -
NIZ25_RS18105 (3709087) 3709087..3709938 + 852 WP_233991701.1 winged helix-turn-helix domain-containing protein -
NIZ25_RS18110 (3709996) 3709996..3710295 - 300 WP_025237546.1 XRE family transcriptional regulator Antitoxin
NIZ25_RS18115 (3710305) 3710305..3710646 - 342 WP_059224977.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ25_RS18120 (3710722) 3710722..3711699 - 978 Protein_3537 flagellar hook-associated protein -
NIZ25_RS18125 (3711716) 3711716..3712645 - 930 WP_025237548.1 flagellar hook-associated protein FlgL -
NIZ25_RS18130 (3712660) 3712660..3714036 - 1377 WP_233991702.1 flagellar hook-associated protein FlgK -
NIZ25_RS18135 (3714594) 3714594..3714893 - 300 WP_059224974.1 rod-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T249552 WP_059224977.1 NZ_CP099868:c3710646-3710305 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT249552 WP_025237546.1 NZ_CP099868:c3710295-3709996 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3T5VD61

References