Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 231587..232290 Replicon chromosome
Accession NZ_CP099837
Organism Nocardiopsis exhalans strain JCM11759T

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NE857_RS01050 Protein ID WP_254419381.1
Coordinates 231587..231967 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NE857_RS01055 Protein ID WP_017579412.1
Coordinates 231964..232290 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE857_RS01020 (NE857_01020) 226967..227467 + 501 WP_039830929.1 tRNA adenosine deaminase-associated protein -
NE857_RS01025 (NE857_01025) 227510..227998 + 489 WP_184367081.1 tRNA adenosine deaminase-associated protein -
NE857_RS01030 (NE857_01030) 228003..228512 + 510 WP_254419378.1 nucleoside deaminase -
NE857_RS01040 (NE857_01040) 228652..229215 - 564 WP_254419379.1 PadR family transcriptional regulator -
NE857_RS01045 (NE857_01045) 229280..231295 - 2016 WP_254419380.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
NE857_RS01050 (NE857_01050) 231587..231967 + 381 WP_254419381.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NE857_RS01055 (NE857_01055) 231964..232290 + 327 WP_017579412.1 XRE family transcriptional regulator Antitoxin
NE857_RS01060 (NE857_01060) 232395..234134 + 1740 WP_254419382.1 pyruvate dehydrogenase -
NE857_RS01065 (NE857_01065) 234208..234840 - 633 WP_254419383.1 maleylpyruvate isomerase family mycothiol-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(23-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-95)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14433.57 Da        Isoelectric Point: 5.6646

>T249524 WP_254419381.1 NZ_CP099837:231587-231967 [Nocardiopsis exhalans]
MVVSWNVILLDEVHDWLLVLAKEDPRSADTVVAAIDMLAEVGPILGRPFVDVISHSRIHNLKELRPRTTGDTAIRVLFVF
DPDRQAVLLVAGDKAGRWKQWYDRNIPLAELRYQRWLDGGYTEERG

Download         Length: 381 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11898.33 Da        Isoelectric Point: 4.9943

>AT249524 WP_017579412.1 NZ_CP099837:231964-232290 [Nocardiopsis exhalans]
MSALARTWGESREEIIAAGGLDEGRIAEIGQGMRAEERAYRLAEVRRRHGIDQTTLAEQLGISQSRVSRIERGELDRSEL
ATIRSYVEALGGTVEIVARFGDEALRVG

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References