Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3914331..3914928 Replicon chromosome
Accession NZ_CP099834
Organism Klebsiella quasipneumoniae strain Y7-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NDO72_RS18895 Protein ID WP_049013659.1
Coordinates 3914611..3914928 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NDO72_RS18890 Protein ID WP_049013658.1
Coordinates 3914331..3914618 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO72_RS18860 (3910519) 3910519..3910767 + 249 WP_002893037.1 DUF1158 domain-containing protein -
NDO72_RS18865 (3910785) 3910785..3911126 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
NDO72_RS18870 (3911157) 3911157..3912272 - 1116 WP_074423618.1 MBL fold metallo-hydrolase -
NDO72_RS18875 (3912452) 3912452..3913036 + 585 WP_023288732.1 TetR/AcrR family transcriptional regulator -
NDO72_RS18880 (3913033) 3913033..3913401 + 369 WP_048296969.1 MmcQ/YjbR family DNA-binding protein -
NDO72_RS18885 (3913521) 3913521..3914174 + 654 WP_023288731.1 oxygen-insensitive NAD(P)H nitroreductase -
NDO72_RS18890 (3914331) 3914331..3914618 - 288 WP_049013658.1 helix-turn-helix transcriptional regulator Antitoxin
NDO72_RS18895 (3914611) 3914611..3914928 - 318 WP_049013659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDO72_RS18900 (3915113) 3915113..3916156 - 1044 WP_032454993.1 DUF2157 domain-containing protein -
NDO72_RS18905 (3916500) 3916500..3917366 - 867 WP_044521465.1 helix-turn-helix transcriptional regulator -
NDO72_RS18910 (3917475) 3917475..3918902 + 1428 WP_048334304.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12102.38 Da        Isoelectric Point: 11.2767

>T249518 WP_049013659.1 NZ_CP099834:c3914928-3914611 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10810.49 Da        Isoelectric Point: 10.2213

>AT249518 WP_049013658.1 NZ_CP099834:c3914618-3914331 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References