Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 47031..47696 Replicon plasmid pYR4
Accession NZ_CP099806
Organism Yersinia ruckeri strain NVI-10705

Toxin (Protein)


Gene name higB Uniprot ID A0A380S9H4
Locus tag LOR96_RS17755 Protein ID WP_038251855.1
Coordinates 47031..47354 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOR96_RS17760 Protein ID WP_004720859.1
Coordinates 47400..47696 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOR96_RS17715 (LOR96_017710) 42079..42585 + 507 WP_126940180.1 antirestriction protein ArdA -
LOR96_RS17720 (LOR96_017715) 42628..42828 + 201 WP_126940179.1 hypothetical protein -
LOR96_RS17725 (LOR96_017720) 43582..43938 + 357 WP_126940178.1 hypothetical protein -
LOR96_RS17730 (LOR96_017725) 44024..44170 + 147 WP_126940177.1 succinate dehydrogenase flavoprotein subunit -
LOR96_RS17735 (LOR96_017730) 44214..45026 + 813 WP_238692894.1 N-6 DNA methylase -
LOR96_RS17740 (LOR96_017735) 45785..46144 + 360 WP_126940175.1 DUF3085 domain-containing protein -
LOR96_RS17745 (LOR96_017740) 46141..46638 + 498 WP_126940174.1 hypothetical protein -
LOR96_RS17750 (LOR96_017745) 46646..46879 - 234 WP_038251853.1 hypothetical protein -
LOR96_RS17755 (LOR96_017750) 47031..47354 + 324 WP_038251855.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOR96_RS17760 (LOR96_017755) 47400..47696 + 297 WP_004720859.1 NadS family protein Antitoxin
LOR96_RS17765 (LOR96_017760) 48184..48997 + 814 Protein_61 DUF932 domain-containing protein -
LOR96_RS17770 (LOR96_017765) 49219..49389 + 171 WP_004720852.1 DUF5983 family protein -
LOR96_RS17775 (LOR96_017770) 49536..49859 - 324 WP_004720850.1 hypothetical protein -
LOR96_RS17780 (LOR96_017775) 50128..50472 + 345 WP_004720848.1 plasmid mobilization protein MobA -
LOR96_RS17785 (LOR96_017780) 50474..52399 + 1926 WP_004720847.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..115589 115589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12416.31 Da        Isoelectric Point: 8.8371

>T249463 WP_038251855.1 NZ_CP099806:47031-47354 [Yersinia ruckeri]
MEYLEFIETPVFSRRRAELLPDDDFRALQEHLLKNHDLGDTISKTGGCKKIRWSREGMGKRGGVRVIYYVITKSGRLYLL
LVYPKNEKDDLTEAEKAVLKSISQQIE

Download         Length: 324 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11027.77 Da        Isoelectric Point: 6.7264

>AT249463 WP_004720859.1 NZ_CP099806:47400-47696 [Yersinia ruckeri]
MKTELFNDLVESMQQMVAIEKGTLSVPAENIHRHRLPDVKSMREASGLKQNEFADVVGVSASLLQSWEQHRRIPSGSSLK
LLMMIERDPAVIDALRTL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380S9H4

Antitoxin

Source ID Structure

References