Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 42099..42745 Replicon plasmid p806883-9-2019b
Accession NZ_CP099756
Organism Escherichia coli strain 806883-9-2019

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NH020_RS26095 Protein ID WP_000269912.1
Coordinates 42398..42745 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NH020_RS26090 Protein ID WP_001673379.1
Coordinates 42099..42398 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH020_RS26055 (NH020_26055) 37269..37517 + 249 WP_000730008.1 hypothetical protein -
NH020_RS26060 (NH020_26060) 37580..37729 + 150 WP_173672731.1 hypothetical protein -
NH020_RS26065 (NH020_26065) 38822..39013 + 192 WP_000183351.1 hypothetical protein -
NH020_RS26070 (NH020_26070) 39010..40191 + 1182 WP_171874464.1 ORF6N domain-containing protein -
NH020_RS26075 (NH020_26075) 40798..41070 - 273 WP_089591621.1 helix-turn-helix domain-containing protein -
NH020_RS26080 (NH020_26080) 41134..41514 - 381 WP_000061763.1 hypothetical protein -
NH020_RS26085 (NH020_26085) 41781..42065 + 285 WP_001673380.1 hypothetical protein -
NH020_RS26090 (NH020_26090) 42099..42398 - 300 WP_001673379.1 XRE family transcriptional regulator Antitoxin
NH020_RS26095 (NH020_26095) 42398..42745 - 348 WP_000269912.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NH020_RS26100 (NH020_26100) 42990..43253 - 264 WP_000424604.1 hypothetical protein -
NH020_RS26105 (NH020_26105) 43277..43564 - 288 WP_000356589.1 hypothetical protein -
NH020_RS26110 (NH020_26110) 44208..45185 - 978 WP_001704997.1 plasmid replication initiator RepA -
NH020_RS26115 (NH020_26115) 45397..45489 + 93 Protein_63 hypothetical protein -
NH020_RS26120 (NH020_26120) 45652..46215 + 564 WP_001523082.1 serine acetyltransferase -
NH020_RS26125 (NH020_26125) 46179..46796 - 618 WP_001523080.1 tail fiber assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..47500 47500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13545.51 Da        Isoelectric Point: 8.8337

>T249436 WP_000269912.1 NZ_CP099756:c42745-42398 [Escherichia coli]
MWTVLFSQRFDDWLNEQEDALQEKVLADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYEKLVRIAEDEFAAHLNTLESK

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11069.90 Da        Isoelectric Point: 5.8899

>AT249436 WP_001673379.1 NZ_CP099756:c42398-42099 [Escherichia coli]
MRTLDEVIASRSPESQARIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRVAFHV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References