Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4918833..4919435 Replicon chromosome
Accession NZ_CP099754
Organism Escherichia coli strain 806883-9-2019

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NH020_RS23755 Protein ID WP_000897305.1
Coordinates 4919124..4919435 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NH020_RS23750 Protein ID WP_000356397.1
Coordinates 4918833..4919123 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH020_RS23730 (4915335) 4915335..4916237 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NH020_RS23735 (4916234) 4916234..4916869 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NH020_RS23740 (4916866) 4916866..4917795 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NH020_RS23745 (4918010) 4918010..4918228 - 219 WP_001298592.1 CopG family transcriptional regulator -
NH020_RS23750 (4918833) 4918833..4919123 - 291 WP_000356397.1 NadS family protein Antitoxin
NH020_RS23755 (4919124) 4919124..4919435 - 312 WP_000897305.1 hypothetical protein Toxin
NH020_RS23760 (4919664) 4919664..4920572 + 909 WP_001318161.1 alpha/beta hydrolase -
NH020_RS23765 (4920636) 4920636..4921577 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NH020_RS23770 (4921622) 4921622..4922059 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NH020_RS23775 (4922056) 4922056..4922928 - 873 WP_000920762.1 virulence factor BrkB family protein -
NH020_RS23780 (4922922) 4922922..4923521 - 600 WP_001314324.1 glucose-1-phosphatase -
NH020_RS23785 (4923620) 4923620..4924405 - 786 WP_000059679.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T249434 WP_000897305.1 NZ_CP099754:c4919435-4919124 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT249434 WP_000356397.1 NZ_CP099754:c4919123-4918833 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References