Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3594510..3595309 Replicon chromosome
Accession NZ_CP099752
Organism Escherichia coli strain 806883-11-2019

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NHF43_RS17290 Protein ID WP_000347273.1
Coordinates 3594510..3594974 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag NHF43_RS17295 Protein ID WP_001307405.1
Coordinates 3594974..3595309 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF43_RS17260 (3589511) 3589511..3589945 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NHF43_RS17265 (3589963) 3589963..3590841 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NHF43_RS17270 (3590831) 3590831..3591610 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NHF43_RS17275 (3591621) 3591621..3592094 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NHF43_RS17280 (3592117) 3592117..3593397 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
NHF43_RS17285 (3593646) 3593646..3594455 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
NHF43_RS17290 (3594510) 3594510..3594974 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NHF43_RS17295 (3594974) 3594974..3595309 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NHF43_RS17300 (3595458) 3595458..3597029 - 1572 WP_001273741.1 galactarate dehydratase -
NHF43_RS17305 (3597404) 3597404..3598738 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NHF43_RS17310 (3598754) 3598754..3599524 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T249408 WP_000347273.1 NZ_CP099752:c3594974-3594510 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT249408 WP_001307405.1 NZ_CP099752:c3595309-3594974 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References