Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1920143..1920684 Replicon chromosome
Accession NZ_CP099752
Organism Escherichia coli strain 806883-11-2019

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag NHF43_RS09335 Protein ID WP_000615982.1
Coordinates 1920406..1920684 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NHF43_RS09330 Protein ID WP_000729704.1
Coordinates 1920143..1920403 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF43_RS09305 (1915926) 1915926..1916711 - 786 WP_000207557.1 putative lateral flagellar export/assembly protein LafU -
NHF43_RS09310 (1916683) 1916683..1918395 + 1713 Protein_1826 flagellar biosynthesis protein FlhA -
NHF43_RS09315 (1918500) 1918500..1918778 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NHF43_RS09320 (1918771) 1918771..1919127 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NHF43_RS09325 (1919184) 1919184..1919957 - 774 WP_000543899.1 C40 family peptidase -
NHF43_RS09330 (1920143) 1920143..1920403 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NHF43_RS09335 (1920406) 1920406..1920684 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NHF43_RS09340 (1920840) 1920840..1921580 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NHF43_RS09345 (1921551) 1921551..1922318 - 768 WP_000333380.1 class II glutamine amidotransferase -
NHF43_RS09350 (1922524) 1922524..1923102 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T249404 WP_000615982.1 NZ_CP099752:1920406-1920684 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT249404 WP_000729704.1 NZ_CP099752:1920143-1920403 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References