Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3935064..3935661 Replicon chromosome
Accession NZ_CP099748
Organism Klebsiella pneumoniae strain 806883-10-2019

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag NHF42_RS19115 Protein ID WP_004893639.1
Coordinates 3935344..3935661 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag NHF42_RS19110 Protein ID WP_004142561.1
Coordinates 3935064..3935351 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF42_RS19080 (NHF42_19070) 3931144..3931392 + 249 WP_002893037.1 DUF1158 domain-containing protein -
NHF42_RS19085 (NHF42_19075) 3931410..3931751 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
NHF42_RS19090 (NHF42_19080) 3931782..3932897 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
NHF42_RS19095 (NHF42_19085) 3933077..3933658 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
NHF42_RS19100 (NHF42_19090) 3933658..3934026 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
NHF42_RS19105 (NHF42_19095) 3934146..3934799 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
NHF42_RS19110 (NHF42_19100) 3935064..3935351 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
NHF42_RS19115 (NHF42_19105) 3935344..3935661 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHF42_RS19120 (NHF42_19110) 3935846..3936889 - 1044 WP_004893645.1 DUF2157 domain-containing protein -
NHF42_RS19125 (NHF42_19115) 3937555..3938421 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
NHF42_RS19130 (NHF42_19120) 3938530..3939957 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T249384 WP_004893639.1 NZ_CP099748:c3935661-3935344 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT249384 WP_004142561.1 NZ_CP099748:c3935351-3935064 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References