Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3896068..3896665 Replicon chromosome
Accession NZ_CP099743
Organism Klebsiella pneumoniae strain 503666-2-2019

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag NHF44_RS18945 Protein ID WP_004893639.1
Coordinates 3896348..3896665 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag NHF44_RS18940 Protein ID WP_004142561.1
Coordinates 3896068..3896355 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF44_RS18910 (NHF44_18900) 3892148..3892396 + 249 WP_002893037.1 DUF1158 domain-containing protein -
NHF44_RS18915 (NHF44_18905) 3892414..3892755 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
NHF44_RS18920 (NHF44_18910) 3892786..3893901 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
NHF44_RS18925 (NHF44_18915) 3894081..3894662 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
NHF44_RS18930 (NHF44_18920) 3894662..3895030 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
NHF44_RS18935 (NHF44_18925) 3895150..3895803 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
NHF44_RS18940 (NHF44_18930) 3896068..3896355 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
NHF44_RS18945 (NHF44_18935) 3896348..3896665 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHF44_RS18950 (NHF44_18940) 3896850..3897893 - 1044 WP_004893645.1 DUF2157 domain-containing protein -
NHF44_RS18955 (NHF44_18945) 3898559..3899425 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
NHF44_RS18960 (NHF44_18950) 3899534..3900961 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T249365 WP_004893639.1 NZ_CP099743:c3896665-3896348 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT249365 WP_004142561.1 NZ_CP099743:c3896355-3896068 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References