Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 376600..377246 Replicon chromosome
Accession NZ_CP099743
Organism Klebsiella pneumoniae strain 503666-2-2019

Toxin (Protein)


Gene name higB Uniprot ID A0A483PC41
Locus tag NHF44_RS01720 Protein ID WP_004216295.1
Coordinates 376600..376947 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag NHF44_RS01725 Protein ID WP_002920557.1
Coordinates 376947..377246 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF44_RS01710 (NHF44_01710) 372526..373959 + 1434 WP_004889438.1 glycogen synthase GlgA -
NHF44_RS01715 (NHF44_01715) 373977..376424 + 2448 WP_002920561.1 glycogen phosphorylase -
NHF44_RS01720 (NHF44_01720) 376600..376947 + 348 WP_004216295.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHF44_RS01725 (NHF44_01725) 376947..377246 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
NHF44_RS01730 (NHF44_01730) 377309..378817 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
NHF44_RS01735 (NHF44_01735) 379022..379351 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NHF44_RS01740 (NHF44_01740) 379402..380232 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NHF44_RS01745 (NHF44_01745) 380282..381040 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13606.61 Da        Isoelectric Point: 5.6749

>T249358 WP_004216295.1 NZ_CP099743:376600-376947 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCADNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT249358 WP_002920557.1 NZ_CP099743:376947-377246 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483PC41

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References