Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-rdlD/SymE(toxin)
Location 4123394..4123806 Replicon chromosome
Accession NZ_CP099721
Organism Escherichia coli strain EC21GDE043

Toxin (Protein)


Gene name symE Uniprot ID A0A8E0IWC4
Locus tag NH569_RS20235 Protein ID WP_001513534.1
Coordinates 4123465..4123806 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4123394..4123470 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH569_RS20225 (4120006) 4120006..4121475 + 1470 WP_001387312.1 type I restriction-modification system subunit M -
NH569_RS20230 (4121475) 4121475..4123244 + 1770 WP_001513535.1 restriction endonuclease subunit S -
- (4123394) 4123394..4123470 - 77 NuclAT_6 - Antitoxin
- (4123394) 4123394..4123470 - 77 NuclAT_6 - Antitoxin
- (4123394) 4123394..4123470 - 77 NuclAT_6 - Antitoxin
- (4123394) 4123394..4123470 - 77 NuclAT_6 - Antitoxin
- (4123394) 4123394..4123470 - 77 NuclAT_7 - Antitoxin
- (4123394) 4123394..4123470 - 77 NuclAT_7 - Antitoxin
- (4123394) 4123394..4123470 - 77 NuclAT_7 - Antitoxin
- (4123394) 4123394..4123470 - 77 NuclAT_7 - Antitoxin
NH569_RS20235 (4123465) 4123465..4123806 + 342 WP_001513534.1 endoribonuclease SymE Toxin
NH569_RS20240 (4123853) 4123853..4125016 - 1164 WP_224153787.1 DUF1524 domain-containing protein -
NH569_RS20245 (4125070) 4125070..4125946 - 877 Protein_3961 DUF262 domain-containing protein -
NH569_RS20250 (4126352) 4126352..4127272 - 921 WP_001513532.1 Rpn family recombination-promoting nuclease/putative transposase -
NH569_RS20255 (4127457) 4127457..4128737 + 1281 WP_001338077.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4107782..4123806 16024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12247.03 Da        Isoelectric Point: 7.8545

>T249331 WP_001513534.1 NZ_CP099721:4123465-4123806 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASHYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT249331 NZ_CP099721:c4123470-4123394 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References