Detailed information of TA system TA024931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 856244..856755
• Replicon: chromosome
• Accession: NC_014614
• Organism: Clostridium sticklandii

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CLOST_RS03895
• Protein ID: WP_013360945.1
• Coordinates: 856492..856755 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1T5BJR0
• Locus tag: CLOST_RS03890
• Protein ID: WP_013360944.1
• Coordinates: 856244..856492 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLOST_RS03875	853565..854320	+	756	WP_013360941.1	GTP pyrophosphokinase family protein	-
CLOST_RS03880	854399..855109	+	711	WP_041487337.1	purine-nucleoside phosphorylase	-
CLOST_RS03885	855150..856058	+	909	WP_013360943.1	GIY-YIG nuclease family protein	-
CLOST_RS03890	856244..856492	+	249	WP_013360944.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CLOST_RS03895	856492..856755	+	264	WP_013360945.1	Txe/YoeB family addiction module toxin	Toxin
CLOST_RS03900	856854..857588	-	735	WP_013360946.1	SIMPL domain-containing protein	-
CLOST_RS13480	857890..859794	+	1905	WP_013360947.1	HD domain-containing protein	-
CLOST_RS03910	859898..860827	-	930	WP_013360948.1	DUF4349 domain-containing protein	-
CLOST_RS03915	861130..861315	+	186	WP_013360949.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10371.23 Da
• Isoelectric Point: 9.9088

>T24931 WP_013360945.1 NC_014614:856492-856755 [[Clostridium] sticklandii]
MYKIVYDKMALKDIPKLKSTNLDKKTKSLIDILRLNPYQSPPPYEKLVGDLEGAYSRRINIQHRLVYQILEDIKTIKIIS
MWSHYEF

Nucleotide

• Length: 264 bp

>T24931 NC_014614:856492-856755 [[Clostridium] sticklandii]
ATGTATAAAATTGTTTATGACAAAATGGCACTAAAGGATATTCCAAAGTTAAAATCAACCAATCTTGACAAAAAAACTAA
ATCATTAATTGATATATTAAGACTTAATCCTTATCAATCTCCACCACCATATGAAAAATTAGTTGGTGACCTTGAGGGAG
CATACTCGAGAAGAATTAATATACAGCATAGACTTGTGTACCAAATTTTAGAGGATATAAAAACAATTAAAATAATCAGC
ATGTGGTCTCATTATGAATTCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9391.55 Da
• Isoelectric Point: 3.9421

>AT24931 WP_013360944.1 NC_014614:856244-856492 [[Clostridium] sticklandii]
VINTNVTNFRKNLFNILEQTIKYNEPVNISTKDGNAVIISEEDYNGLMETLYLCSIPNMREKIMSSINTSVDECVAEDEV
DW

Nucleotide

• Length: 249 bp

>AT24931 NC_014614:856244-856492 [[Clostridium] sticklandii]
GTGATTAATACGAATGTCACTAATTTTAGAAAAAATTTATTCAATATCCTAGAACAGACCATAAAATATAATGAACCAGT
AAATATAAGTACAAAAGATGGAAATGCAGTTATAATAAGTGAAGAAGACTATAATGGTTTGATGGAGACTTTGTATCTTT
GTTCAATTCCAAATATGAGAGAAAAAATCATGAGCAGTATAAATACCTCTGTAGATGAATGTGTAGCAGAAGACGAGGTC
GATTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1T5BJR0