249298

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2445203..2445725 Replicon chromosome
Accession NZ_CP099705
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013+

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NG892_RS12020 Protein ID WP_000221343.1
Coordinates 2445441..2445725 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NG892_RS12015 Protein ID WP_000885424.1
Coordinates 2445203..2445451 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG892_RS11990 (2440419) 2440419..2441885 + 1467 WP_000987828.1 hypothetical protein -
NG892_RS11995 (2442693) 2442693..2443407 + 715 Protein_2344 helix-turn-helix domain-containing protein -
NG892_RS12000 (2443463) 2443463..2444371 - 909 WP_010989018.1 hypothetical protein -
NG892_RS12005 (2444514) 2444514..2444846 - 333 WP_000253154.1 DUF1493 family protein -
NG892_RS12010 (2444836) 2444836..2445051 - 216 WP_000206207.1 hypothetical protein -
NG892_RS12015 (2445203) 2445203..2445451 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NG892_RS12020 (2445441) 2445441..2445725 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NG892_RS12025 (2445896) 2445896..2446285 + 390 WP_000194089.1 RidA family protein -
NG892_RS12030 (2446337) 2446337..2447416 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NG892_RS12035 (2447609) 2447609..2448097 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
NG892_RS12040 (2448142) 2448142..2449650 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2440422..2452507 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T249298 WP_000221343.1 NZ_CP099705:2445441-2445725 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT249298 WP_000885424.1 NZ_CP099705:2445203-2445451 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References