Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3777567..3778320 Replicon chromosome
Accession NZ_CP099647
Organism Paraburkholderia fungorum strain OTU2SAUBB1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NHH62_RS36055 Protein ID WP_030101206.1
Coordinates 3777567..3777848 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NHH62_RS36060 Protein ID WP_030101205.1
Coordinates 3777865..3778320 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHH62_RS36045 (NHH62_36040) 3773717..3774424 - 708 WP_028200136.1 DUF4136 domain-containing protein -
NHH62_RS36050 (NHH62_36045) 3774648..3777344 + 2697 WP_253045448.1 aminopeptidase N -
NHH62_RS36055 (NHH62_36050) 3777567..3777848 + 282 WP_030101206.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHH62_RS36060 (NHH62_36055) 3777865..3778320 + 456 WP_030101205.1 HigA family addiction module antitoxin Antitoxin
NHH62_RS36065 (NHH62_36060) 3778442..3779458 + 1017 WP_028200141.1 class 1 fructose-bisphosphatase -
NHH62_RS36075 (NHH62_36070) 3779667..3779867 - 201 WP_035519916.1 hypothetical protein -
NHH62_RS36080 (NHH62_36075) 3780030..3780941 - 912 WP_253045449.1 LysR family transcriptional regulator -
NHH62_RS36085 (NHH62_36080) 3781070..3782185 + 1116 WP_030101203.1 aldo/keto reductase -
NHH62_RS36090 (NHH62_36085) 3782694..3782843 + 150 WP_028200145.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(24-99)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10577.22 Da        Isoelectric Point: 9.0944

>T249284 WP_030101206.1 NZ_CP099647:3777567-3777848 [Paraburkholderia fungorum]
MITTFGDKATAAIFHGKFVHSLPLYMQALARRKLLMIDAAESIRSLHAPPGNRLEALQGQRSGQWSIRINAQWRICFHFV
DGETLNVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16329.85 Da        Isoelectric Point: 10.3611

>AT249284 WP_030101205.1 NZ_CP099647:3777865-3778320 [Paraburkholderia fungorum]
MVIKRSDLGSIDFSDIGTAESIPETPPGEILRSEFLEPLGMSVNALALALRVPAPRINDIVRGKRAISADTALRLERYFG
ASAQFWLNLQIAYDLRVATAAAGEQIEREIEPMPRANRPKLPKVSAEHARAAALAASLTGNVTAIKARRKA

Download         Length: 456 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References