Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3941306..3942059 Replicon chromosome
Accession NZ_CP099627
Organism Paraburkholderia fungorum strain OTU2BAGNBA2

Toxin (Protein)


Gene name graT Uniprot ID A0A0D5V7W6
Locus tag NFS19_RS17485 Protein ID WP_028200139.1
Coordinates 3941306..3941587 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFS19_RS17490 Protein ID WP_046568014.1
Coordinates 3941604..3942059 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFS19_RS17475 (NFS19_17470) 3937456..3938163 - 708 WP_028200136.1 DUF4136 domain-containing protein -
NFS19_RS17480 (NFS19_17475) 3938387..3941083 + 2697 WP_252888335.1 aminopeptidase N -
NFS19_RS17485 (NFS19_17480) 3941306..3941587 + 282 WP_028200139.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFS19_RS17490 (NFS19_17485) 3941604..3942059 + 456 WP_046568014.1 HigA family addiction module antitoxin Antitoxin
NFS19_RS17495 (NFS19_17490) 3942181..3943197 + 1017 WP_028200141.1 class 1 fructose-bisphosphatase -
NFS19_RS17505 (NFS19_17500) 3943449..3944825 + 1377 WP_252888336.1 tyrosine-type recombinase/integrase -
NFS19_RS17510 (NFS19_17505) 3944822..3945772 - 951 WP_252888337.1 ParB N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10547.19 Da        Isoelectric Point: 9.0944

>T249275 WP_028200139.1 NZ_CP099627:3941306-3941587 [Paraburkholderia fungorum]
MITTFGDKATAAIFHGKFVHSLPLYMQALARRKLLMIDAAESIRSLHAPPGNRLEALQGQRSGQWSIRINAQWRICFHFV
DGEALNVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16369.88 Da        Isoelectric Point: 10.3612

>AT249275 WP_046568014.1 NZ_CP099627:3941604-3942059 [Paraburkholderia fungorum]
MVIKRSELGSIDFSDIGTGESIPETHPGEILRSEFLEPLGMSVNALALALRVPAPRINDIVRGKRAISADTALRLERYFG
ASAQFWLNLQIAYDLRVATAAAGEQIEREIEPMPRANRPKLPKVSAEHARAAALAASLTGNVTAIKARRKA

Download         Length: 456 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D5V7W6

Antitoxin

Source ID Structure

References