Detailed information of TA system TA024927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1793190..1793910
• Replicon: chromosome
• Accession: NC_014562
• Organism: Pantoea vagans C9-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: PVAG_RS12445
• Protein ID: WP_041456921.1
• Coordinates: 1793190..1793504 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: PVAG_RS12450
• Protein ID: WP_033783335.1
• Coordinates: 1793578..1793910 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PVAG_RS12430	1789224..1790954	+	1731	WP_013358217.1	arginine--tRNA ligase	-
PVAG_RS12435	1791045..1791992	+	948	WP_013358218.1	LysR family transcriptional regulator	-
PVAG_RS12440	1792117..1793115	+	999	WP_013358219.1	aldo/keto reductase	-
PVAG_RS12445	1793190..1793504	+	315	WP_041456921.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PVAG_RS12450	1793578..1793910	+	333	WP_033783335.1	HigA family addiction module antidote protein	Antitoxin
PVAG_RS12455	1794069..1794461	-	393	WP_013358221.1	flagellar protein FlhE	-
PVAG_RS12460	1794461..1796560	-	2100	WP_013358222.1	flagellar biosynthesis protein FlhA	-
PVAG_RS12465	1796553..1797704	-	1152	WP_013358223.1	flagellar type III secretion system protein FlhB	-
PVAG_RS12470	1797893..1798534	-	642	WP_013358224.1	protein phosphatase CheZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (7-100)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-99)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12169.91 Da
• Isoelectric Point: 9.8819

>T24927 WP_041456921.1 NC_014562:1793190-1793504 [Pantoea vagans C9-1]
VATLRNIESFRDDWLENYFLYGKYSKRIPSTLSSALARKLDIINAAISFKDLRSPPGNRYEELNPPLEGYASIRVNKQYR
LIFKWIEGKAVDLYLDAHSYKTHK

Nucleotide

• Length: 315 bp

>T24927 NC_014562:1793190-1793504 [Pantoea vagans C9-1]
GTGGCGACGTTAAGAAACATCGAAAGCTTCAGGGATGACTGGCTTGAGAATTATTTTTTATATGGCAAATATTCTAAAAG
AATACCCTCAACCCTTTCATCCGCATTGGCGCGAAAGCTCGACATCATCAATGCAGCGATTAGTTTTAAAGATCTGAGGT
CGCCGCCTGGCAACCGTTATGAGGAGCTGAACCCGCCTCTTGAGGGATACGCTTCGATCAGGGTCAATAAGCAATATCGG
CTGATTTTTAAGTGGATAGAAGGTAAGGCCGTTGACCTTTATCTGGACGCGCATAGCTATAAAACGCACAAGTGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12559.38 Da
• Isoelectric Point: 5.1358

>AT24927 WP_033783335.1 NC_014562:1793578-1793910 [Pantoea vagans C9-1]
MNQATRKPTTVGDVLLYEYLEPTGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFDTSVEFWLNLQNSVDIW
EVMHDARAQEEISRVTPLKDFLAQKENQVA

Nucleotide

• Length: 333 bp

>AT24927 NC_014562:1793578-1793910 [Pantoea vagans C9-1]
ATGAACCAGGCAACCCGCAAACCGACCACTGTCGGCGATGTATTACTTTACGAATATCTGGAGCCAACCGGCCTGAAGAT
TCTCGACTTAGCGGAGATGCTCAAGGTGCACCGCAACACGGTCAGTGCCCTGGTGAACAACAACCGGAAGCTGACGCCGG
ATATGGCTTTCAGGCTGGCGGCAGCCTTTGACACCAGCGTTGAGTTCTGGCTTAACCTGCAAAACAGTGTCGATATCTGG
GAAGTCATGCATGACGCCAGGGCTCAGGAGGAGATCAGCCGCGTAACGCCCTTAAAGGATTTTCTGGCGCAGAAAGAGAA
TCAGGTGGCGTGA