249248

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5115244..5115824 Replicon chromosome
Accession NZ_CP099608
Organism Pseudomonas moraviensis strain OTU5BARRA1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NF672_RS22665 Protein ID WP_252874558.1
Coordinates 5115244..5115522 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NF672_RS22670 Protein ID WP_016773085.1
Coordinates 5115537..5115824 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF672_RS22645 (NF672_22645) 5110820..5110987 - 168 WP_016773090.1 DUF2474 domain-containing protein -
NF672_RS22650 (NF672_22650) 5111072..5112079 - 1008 WP_042610525.1 cytochrome d ubiquinol oxidase subunit II -
NF672_RS22655 (NF672_22655) 5112083..5113528 - 1446 WP_042610526.1 cytochrome ubiquinol oxidase subunit I -
NF672_RS22660 (NF672_22660) 5113909..5115144 + 1236 WP_042610527.1 MFS transporter -
NF672_RS22665 (NF672_22665) 5115244..5115522 + 279 WP_252874558.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NF672_RS22670 (NF672_22670) 5115537..5115824 + 288 WP_016773085.1 HigA family addiction module antitoxin Antitoxin
NF672_RS22675 (NF672_22675) 5115829..5116380 - 552 WP_252873390.1 DJ-1/PfpI family protein -
NF672_RS22680 (NF672_22680) 5116448..5116894 - 447 WP_042610529.1 DUF4879 domain-containing protein -
NF672_RS22685 (NF672_22685) 5117115..5118410 + 1296 WP_252873391.1 NCS2 family permease -
NF672_RS22690 (NF672_22690) 5118407..5119486 + 1080 WP_064364087.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
NF672_RS22695 (NF672_22695) 5119541..5119987 - 447 WP_252873392.1 DUF2442 domain-containing protein -
NF672_RS22700 (NF672_22700) 5119984..5120412 - 429 WP_083353612.1 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10745.31 Da        Isoelectric Point: 9.6228

>T249248 WP_252874558.1 NZ_CP099608:5115244-5115522 [Pseudomonas moraviensis]
MIKSFQHKGLRGFYETGTTRGIRAEHAKRLSRMLQFMDRATLPGDLDLPGWRLHPLKGELSEHWSLSVSGNWRVIFRFVG
SDIELVDYLDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10525.13 Da        Isoelectric Point: 6.6962

>AT249248 WP_016773085.1 NZ_CP099608:5115537-5115824 [Pseudomonas moraviensis]
MPMHNPPHPGETLLLDVLPELGISVSELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EHREQPMIEPLAAHG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References