Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 294077..294681 Replicon chromosome
Accession NZ_CP099608
Organism Pseudomonas moraviensis strain OTU5BARRA1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NF672_RS01270 Protein ID WP_064363397.1
Coordinates 294367..294681 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1N7CI26
Locus tag NF672_RS01265 Protein ID WP_064363398.1
Coordinates 294077..294364 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF672_RS01245 (NF672_01245) 289852..290256 + 405 WP_042608583.1 S4 domain-containing protein -
NF672_RS01250 (NF672_01250) 290415..291218 - 804 WP_159244943.1 phosphatase PAP2 family protein -
NF672_RS01255 (NF672_01255) 291325..292227 + 903 WP_252873705.1 Hsp33 family molecular chaperone HslO -
NF672_RS01260 (NF672_01260) 292409..293950 + 1542 WP_016772179.1 phosphoenolpyruvate carboxykinase -
NF672_RS01265 (NF672_01265) 294077..294364 - 288 WP_064363398.1 NadS family protein Antitoxin
NF672_RS01270 (NF672_01270) 294367..294681 - 315 WP_064363397.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NF672_RS01275 (NF672_01275) 294787..295086 - 300 WP_064363396.1 hypothetical protein -
NF672_RS01280 (NF672_01280) 295432..296574 - 1143 WP_252873706.1 hypothetical protein -
NF672_RS01285 (NF672_01285) 296872..298806 + 1935 WP_083353978.1 ATP-dependent DNA helicase RecQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-73)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11614.29 Da        Isoelectric Point: 9.8054

>T249240 WP_064363397.1 NZ_CP099608:c294681-294367 [Pseudomonas moraviensis]
MIFIETSVFTRRVRELLDDDAYATFQKQLVADPSIGDVIEGTGGVRKARVASKGHGKRGGAGVIYYHFVSASQIALLMIY
SKNEQQDLTHDERKALKAMIGNWR

Download         Length: 315 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10727.38 Da        Isoelectric Point: 8.7453

>AT249240 WP_064363398.1 NZ_CP099608:c294364-294077 [Pseudomonas moraviensis]
MSKFFDELMESVQEMDEILRGEKKPSREFHVDALQVKQIRKATGMTQAKFAALIDVQLGTLRNWEQGRRQPTGPAKALLK
AIHNDPVHVLSALAD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1N7CI26

References