249219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5064981..5065561 Replicon chromosome
Accession NZ_CP099600
Organism Pseudomonas siliginis strain OTU6MEDAA1

Toxin (Protein)


Gene name higB Uniprot ID A0A554AH63
Locus tag NF678_RS22425 Protein ID WP_041477766.1
Coordinates 5064981..5065259 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NF678_RS22430 Protein ID WP_016773085.1
Coordinates 5065274..5065561 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF678_RS22405 (NF678_22405) 5060467..5060634 - 168 WP_016773090.1 DUF2474 domain-containing protein -
NF678_RS22410 (NF678_22410) 5060719..5061726 - 1008 WP_016773089.1 cytochrome d ubiquinol oxidase subunit II -
NF678_RS22415 (NF678_22415) 5061730..5063175 - 1446 WP_041477768.1 cytochrome ubiquinol oxidase subunit I -
NF678_RS22420 (NF678_22420) 5063645..5064880 + 1236 WP_252882711.1 MFS transporter -
NF678_RS22425 (NF678_22425) 5064981..5065259 + 279 WP_041477766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NF678_RS22430 (NF678_22430) 5065274..5065561 + 288 WP_016773085.1 HigA family addiction module antitoxin Antitoxin
NF678_RS22435 (NF678_22435) 5065566..5066117 - 552 WP_150742273.1 DJ-1/PfpI family protein -
NF678_RS22440 (NF678_22440) 5066185..5066631 - 447 WP_252868318.1 DUF4879 domain-containing protein -
NF678_RS22445 (NF678_22445) 5066852..5068147 + 1296 WP_016773083.1 NCS2 family permease -
NF678_RS22450 (NF678_22450) 5068144..5069223 + 1080 WP_252882712.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
NF678_RS22455 (NF678_22455) 5069494..5069934 + 441 WP_252882713.1 type II 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10771.34 Da        Isoelectric Point: 9.5056

>T249219 WP_041477766.1 NZ_CP099600:5064981-5065259 [Pseudomonas siliginis]
MIKSFQHKGLRGFYETGTTRGIRADHAKRLSRMLQFMDRATLPADLDLPGWRLHPLKGELSEYWSLSVSGNWRVIFRFVG
SDIELVDYLDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10525.13 Da        Isoelectric Point: 6.6962

>AT249219 WP_016773085.1 NZ_CP099600:5065274-5065561 [Pseudomonas siliginis]
MPMHNPPHPGETLLLDVLPELGISVSELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EHREQPMIEPLAAHG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554AH63

Antitoxin

Source ID Structure

References