Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5110842..5111422 Replicon chromosome
Accession NZ_CP099599
Organism Pseudomonas siliginis strain OTU6ESPEB1

Toxin (Protein)


Gene name higB Uniprot ID A0A554AH63
Locus tag NF677_RS22845 Protein ID WP_041477766.1
Coordinates 5110842..5111120 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NF677_RS22850 Protein ID WP_016773085.1
Coordinates 5111135..5111422 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF677_RS22825 (NF677_22825) 5106326..5106493 - 168 WP_016773090.1 DUF2474 domain-containing protein -
NF677_RS22830 (NF677_22830) 5106578..5107585 - 1008 WP_016773089.1 cytochrome d ubiquinol oxidase subunit II -
NF677_RS22835 (NF677_22835) 5107589..5109034 - 1446 WP_024014409.1 cytochrome ubiquinol oxidase subunit I -
NF677_RS22840 (NF677_22840) 5109506..5110741 + 1236 WP_252884863.1 MFS transporter -
NF677_RS22845 (NF677_22845) 5110842..5111120 + 279 WP_041477766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NF677_RS22850 (NF677_22850) 5111135..5111422 + 288 WP_016773085.1 HigA family addiction module antitoxin Antitoxin
NF677_RS22855 (NF677_22855) 5111427..5111978 - 552 WP_041477765.1 DJ-1/PfpI family protein -
NF677_RS22860 (NF677_22860) 5112046..5112492 - 447 WP_252868318.1 DUF4879 domain-containing protein -
NF677_RS22865 (NF677_22865) 5112713..5114008 + 1296 WP_016773083.1 NCS2 family permease -
NF677_RS22870 (NF677_22870) 5114005..5115084 + 1080 WP_252882712.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
NF677_RS22875 (NF677_22875) 5115139..5115585 - 447 WP_252884864.1 DUF2442 domain-containing protein -
NF677_RS22880 (NF677_22880) 5115582..5116010 - 429 WP_252884865.1 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10771.34 Da        Isoelectric Point: 9.5056

>T249213 WP_041477766.1 NZ_CP099599:5110842-5111120 [Pseudomonas siliginis]
MIKSFQHKGLRGFYETGTTRGIRADHAKRLSRMLQFMDRATLPADLDLPGWRLHPLKGELSEYWSLSVSGNWRVIFRFVG
SDIELVDYLDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10525.13 Da        Isoelectric Point: 6.6962

>AT249213 WP_016773085.1 NZ_CP099599:5111135-5111422 [Pseudomonas siliginis]
MPMHNPPHPGETLLLDVLPELGISVSELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EHREQPMIEPLAAHG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554AH63

Antitoxin

Source ID Structure

References