24920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1554266..1554854 Replicon chromosome
Accession NC_014555
Organism Helicobacter pylori PeCan4

Toxin (Protein)


Gene name TfiT Uniprot ID Q6RWC1
Locus tag HPPC_RS07490 Protein ID WP_000921939.1
Coordinates 1554266..1554547 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID E1Q5D4
Locus tag HPPC_RS07495 Protein ID WP_000073113.1
Coordinates 1554540..1554854 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPPC_RS07460 1549468..1549767 + 300 WP_000660147.1 hypothetical protein -
HPPC_RS07465 1549767..1550708 + 942 WP_000625143.1 Flp pilus assembly complex ATPase component TadA -
HPPC_RS07470 1550705..1551160 + 456 WP_000795446.1 hypothetical protein -
HPPC_RS07475 1551157..1551447 + 291 WP_000159813.1 hypothetical protein -
HPPC_RS07480 1551448..1552005 + 558 WP_001167795.1 hypothetical protein -
HPPC_RS07485 1552006..1553754 + 1749 WP_000570348.1 type IV secretory system conjugative DNA transfer family protein -
HPPC_RS07490 1554266..1554547 - 282 WP_000921939.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPPC_RS07495 1554540..1554854 - 315 WP_000073113.1 hypothetical protein Antitoxin
HPPC_RS07500 1555149..1557059 + 1911 WP_001162721.1 relaxase/mobilization nuclease domain-containing protein -
HPPC_RS07505 1557084..1558256 - 1173 WP_000753635.1 hypothetical protein -
HPPC_RS07510 1558300..1558584 - 285 WP_000394659.1 hypothetical protein -
HPPC_RS07515 1558663..1559319 - 657 WP_000587383.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1496741..1562797 66056


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10905.83 Da        Isoelectric Point: 9.5726

>T24920 WP_000921939.1 NC_014555:c1554547-1554266 [Helicobacter pylori PeCan4]
MLKVRTKKDFLKDFNKHILSGRITESDVTSIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T24920 NC_014555:c1554547-1554266 [Helicobacter pylori PeCan4]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTGTCTGGGCGTATTACAGAAAGCGA
TGTTACAAGTATTGTTGATTGCCTAAAAGAACAAAAACCACTCCAACAAAAATATTGCGACCATGCTTTGAGCGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12152.57 Da        Isoelectric Point: 5.2068

>AT24920 WP_000073113.1 NC_014555:c1554854-1554540 [Helicobacter pylori PeCan4]
MSNVITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT24920 NC_014555:c1554854-1554540 [Helicobacter pylori PeCan4]
ATGTCAAATGTTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAGG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACCAAGTTTGTTAAATACGATCGCCTCAAAAGATGATCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4ZKZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A060CZW8

References