Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 3978217..3978629 Replicon chromosome
Accession NZ_CP099588
Organism Escherichia coli strain EMG2

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag NHF38_RS19455 Protein ID WP_000132601.1
Coordinates 3978288..3978629 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 3978217..3978293 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHF38_RS19445 (3975080) 3975080..3976669 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
NHF38_RS19450 (3976666) 3976666..3978060 + 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
- (3978217) 3978217..3978293 - 77 NuclAT_14 - Antitoxin
- (3978217) 3978217..3978293 - 77 NuclAT_14 - Antitoxin
- (3978217) 3978217..3978293 - 77 NuclAT_14 - Antitoxin
- (3978217) 3978217..3978293 - 77 NuclAT_14 - Antitoxin
- (3978217) 3978217..3978293 - 77 NuclAT_15 - Antitoxin
- (3978217) 3978217..3978293 - 77 NuclAT_15 - Antitoxin
- (3978217) 3978217..3978293 - 77 NuclAT_15 - Antitoxin
- (3978217) 3978217..3978293 - 77 NuclAT_15 - Antitoxin
NHF38_RS19455 (3978288) 3978288..3978629 + 342 WP_000132601.1 endoribonuclease SymE Toxin
NHF38_RS19460 (3978791) 3978791..3980170 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
NHF38_RS19465 (3980170) 3980170..3981216 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T249152 WP_000132601.1 NZ_CP099588:3978288-3978629 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT249152 NZ_CP099588:c3978293-3978217 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References