249126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2592115..2592638 Replicon chromosome
Accession NZ_CP099576
Organism Staphylococcus aureus strain MRSA1369

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag NHB12_RS13065 Protein ID WP_000074048.1
Coordinates 2592115..2592381 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag NHB12_RS13070 Protein ID WP_000587616.1
Coordinates 2592381..2592638 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB12_RS13045 (2587422) 2587422..2588609 - 1188 WP_000026194.1 MFS transporter -
NHB12_RS13050 (2589005) 2589005..2589781 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NHB12_RS13055 (2589774) 2589774..2590436 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
NHB12_RS13060 (2590684) 2590684..2591760 - 1077 WP_001076671.1 M42 family metallopeptidase -
NHB12_RS13065 (2592115) 2592115..2592381 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
NHB12_RS13070 (2592381) 2592381..2592638 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NHB12_RS13075 (2592744) 2592744..2592938 - 195 WP_001790145.1 hypothetical protein -
NHB12_RS13080 (2592997) 2592997..2593452 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NHB12_RS13085 (2593620) 2593620..2595197 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
NHB12_RS13090 (2595392) 2595392..2596141 + 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
NHB12_RS13095 (2596365) 2596365..2597558 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T249126 WP_000074048.1 NZ_CP099576:c2592381-2592115 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT249126 WP_000587616.1 NZ_CP099576:c2592638-2592381 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z


Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References