249125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2560615..2560799 Replicon chromosome
Accession NZ_CP099576
Organism Staphylococcus aureus strain MRSA1369

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag NHB12_RS12925 Protein ID WP_000482650.1
Coordinates 2560692..2560799 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2560615..2560675 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB12_RS12910 2556145..2556312 - 168 WP_001790576.1 hypothetical protein -
NHB12_RS12915 2556543..2558276 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
NHB12_RS12920 2558301..2560064 - 1764 WP_001064838.1 ABC transporter ATP-binding protein -
- 2560615..2560675 + 61 - - Antitoxin
NHB12_RS12925 2560692..2560799 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
NHB12_RS12930 2560933..2561319 - 387 WP_000779358.1 flippase GtxA -
NHB12_RS12935 2561587..2562729 + 1143 WP_001176863.1 glycerate kinase -
NHB12_RS12940 2562789..2563448 + 660 WP_000831298.1 membrane protein -
NHB12_RS12945 2563630..2564841 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
NHB12_RS12950 2564964..2565437 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T249125 WP_000482650.1 NZ_CP099576:c2560799-2560692 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT249125 NZ_CP099576:2560615-2560675 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References