Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2535297..2535814 Replicon chromosome
Accession NZ_CP099576
Organism Staphylococcus aureus strain MRSA1369

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NHB12_RS12790 Protein ID WP_000113262.1
Coordinates 2535297..2535563 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag NHB12_RS12795 Protein ID WP_000584502.1
Coordinates 2535563..2535814 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB12_RS12760 (2530723) 2530723..2531259 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
NHB12_RS12765 (2531492) 2531492..2532316 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NHB12_RS12770 (2532533) 2532533..2532715 - 183 WP_000230294.1 hypothetical protein -
NHB12_RS12775 (2532799) 2532799..2533266 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NHB12_RS12780 (2533452) 2533452..2535002 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NHB12_RS12785 (2535191) 2535191..2535262 - 72 Protein_2474 hypothetical protein -
NHB12_RS12790 (2535297) 2535297..2535563 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NHB12_RS12795 (2535563) 2535563..2535814 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NHB12_RS12800 (2535979) 2535979..2536080 - 102 WP_001791744.1 hypothetical protein -
NHB12_RS12805 (2536087) 2536087..2536686 - 600 WP_000162813.1 DsbA family protein -
NHB12_RS12810 (2536705) 2536705..2537064 - 360 WP_000819847.1 DUF4467 domain-containing protein -
NHB12_RS12815 (2537319) 2537319..2538569 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
NHB12_RS12820 (2538666) 2538666..2539397 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NHB12_RS12825 (2539394) 2539394..2540113 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T249124 WP_000113262.1 NZ_CP099576:c2535563-2535297 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT249124 WP_000584502.1 NZ_CP099576:c2535814-2535563 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References