Detailed information of TA system TA249123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2270589..2270806
• Replicon: chromosome
• Accession: NZ_CP099576
• Organism: Staphylococcus aureus strain MRSA1369

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: NHB12_RS11400
• Protein ID: WP_001802298.1
• Coordinates: 2270702..2270806 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2270589..2270644 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NHB12_RS11375	2266726..2267391	-	666	WP_001024094.1	SDR family oxidoreductase	-
NHB12_RS11380	2267543..2267863	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
NHB12_RS11385	2267865..2268845	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
NHB12_RS11390	2269111..2270202	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2270589..2270644	+	56	-	-	Antitoxin
NHB12_RS11400	2270702..2270806	-	105	WP_001802298.1	hypothetical protein	Toxin
NHB12_RS11405	2270967..2271450	-	484	Protein_2207	recombinase family protein	-
NHB12_RS11410	2271493..2272629	-	1137	WP_000115564.1	SAP domain-containing protein	-
NHB12_RS11415	2272918..2273010	+	93	WP_001790138.1	hypothetical protein	-
NHB12_RS11420	2273299..2273483	+	185	Protein_2210	exotoxin	-
NHB12_RS11425	2273715..2274572	-	858	WP_000370924.1	HAD family hydrolase	-
NHB12_RS11430	2274640..2275422	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T249123 WP_001802298.1 NZ_CP099576:c2270806-2270702 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT249123 NZ_CP099576:2270589-2270644 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin