249118

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2095922..2096221 Replicon chromosome
Accession NZ_CP099576
Organism Staphylococcus aureus strain MRSA1369

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag NHB12_RS10405 Protein ID WP_011447039.1
Coordinates 2096045..2096221 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2095922..2095977 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHB12_RS10365 2091253..2091513 + 261 WP_001791826.1 hypothetical protein -
NHB12_RS10370 2091566..2091916 - 351 WP_000702263.1 complement inhibitor SCIN-A -
NHB12_RS10375 2092601..2093050 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
NHB12_RS10380 2093145..2093480 - 336 Protein_2007 SH3 domain-containing protein -
NHB12_RS10385 2094130..2094621 - 492 WP_000919350.1 staphylokinase -
NHB12_RS10390 2094812..2095567 - 756 WP_000861038.1 CHAP domain-containing protein -
NHB12_RS10395 2095579..2095833 - 255 WP_000611512.1 phage holin -
NHB12_RS10400 2095885..2095992 + 108 WP_001791821.1 hypothetical protein -
- 2095914..2096053 + 140 NuclAT_0 - -
- 2095914..2096053 + 140 NuclAT_0 - -
- 2095914..2096053 + 140 NuclAT_0 - -
- 2095914..2096053 + 140 NuclAT_0 - -
- 2095922..2095977 + 56 - - Antitoxin
NHB12_RS10405 2096045..2096221 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
NHB12_RS10410 2096371..2096667 - 297 WP_000539688.1 DUF2951 domain-containing protein -
NHB12_RS10415 2096725..2097012 - 288 WP_001040261.1 hypothetical protein -
NHB12_RS10420 2097059..2097211 - 153 WP_001153681.1 hypothetical protein -
NHB12_RS10425 2097201..2100986 - 3786 WP_000582165.1 phage tail spike protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2091566..2147514 55948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T249118 WP_011447039.1 NZ_CP099576:c2096221-2096045 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT249118 NZ_CP099576:2095922-2095977 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References