Detailed information of TA system TA249116

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1934933..1935115
• Replicon: chromosome
• Accession: NZ_CP099576
• Organism: Staphylococcus aureus strain MRSA1369

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: NHB12_RS09425
• Protein ID: WP_001801861.1
• Coordinates: 1934933..1935028 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1935056..1935115 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NHB12_RS09385	1930593..1931219	+	627	Protein_1847	hypothetical protein	-
NHB12_RS09390	1931260..1931604	+	345	WP_000627551.1	DUF3969 family protein	-
NHB12_RS09395	1931702..1932253	+	552	WP_000414205.1	hypothetical protein	-
NHB12_RS09400	1932471..1933112	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
NHB12_RS09405	1933226..1933411	-	186	WP_000809857.1	hypothetical protein	-
NHB12_RS09410	1933413..1933589	-	177	WP_000375476.1	hypothetical protein	-
NHB12_RS09415	1933600..1933983	-	384	WP_000070811.1	hypothetical protein	-
NHB12_RS09420	1934587..1934730	-	144	WP_001549059.1	transposase	-
NHB12_RS09425	1934933..1935028	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1935056..1935115	-	60	-	-	Antitoxin
NHB12_RS09430	1935151..1935252	+	102	WP_001791893.1	hypothetical protein	-
NHB12_RS09435	1935230..1935406	-	177	Protein_1857	transposase	-
NHB12_RS09440	1935600..1935977	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T249116 WP_001801861.1 NZ_CP099576:1934933-1935028 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

Antitoxin

Nucleotide

• Length: 60 bp

>AT249116 NZ_CP099576:c1935115-1935056 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin