Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1060769..1061274 Replicon chromosome
Accession NZ_CP099556
Organism Aliarcobacter cryaerophilus strain ICDCAC48

Toxin (Protein)


Gene name yoeB Uniprot ID A0A494T483
Locus tag NGX11_RS05350 Protein ID WP_066157207.1
Coordinates 1061008..1061274 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1V9VC04
Locus tag NGX11_RS05345 Protein ID WP_066157209.1
Coordinates 1060769..1061014 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGX11_RS05320 (NGX11_05295) 1055846..1056439 + 594 WP_263514010.1 M48 family metallopeptidase -
NGX11_RS05325 (NGX11_05300) 1056441..1056881 - 441 WP_187471306.1 DUF721 domain-containing protein -
NGX11_RS05330 (NGX11_05305) 1056986..1058437 + 1452 WP_263514011.1 FAD-binding protein -
NGX11_RS05335 (NGX11_05310) 1058491..1060026 + 1536 WP_260892561.1 glutamine-hydrolyzing GMP synthase -
NGX11_RS05340 (NGX11_05315) 1060265..1060567 + 303 WP_263514012.1 HNH endonuclease -
NGX11_RS05345 (NGX11_05320) 1060769..1061014 + 246 WP_066157209.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NGX11_RS05350 (NGX11_05325) 1061008..1061274 + 267 WP_066157207.1 Txe/YoeB family addiction module toxin Toxin
NGX11_RS05355 (NGX11_05330) 1061284..1062999 - 1716 WP_263514013.1 protein adenylyltransferase SelO family protein -
NGX11_RS05360 (NGX11_05335) 1063150..1064448 + 1299 WP_141046414.1 M99 family carboxypeptidase catalytic domain-containing protein -
NGX11_RS05365 (NGX11_05340) 1064473..1064667 - 195 WP_066348707.1 DUF2892 domain-containing protein -
NGX11_RS05370 (NGX11_05345) 1064828..1065532 + 705 WP_263514014.1 alpha/beta hydrolase -
NGX11_RS05375 (NGX11_05350) 1065586..1066179 + 594 WP_263514015.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 925490..1118718 193228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(24-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10229.96 Da        Isoelectric Point: 9.9946

>T249109 WP_066157207.1 NZ_CP099556:1061008-1061274 [Aliarcobacter cryaerophilus]
MVNYKLVYTKQAGKDAKKLSNSGLKSKALELLEIISLNPYQNPPPYEKLIGDLNSAISRRINIQHRLVYEVLEDIKTIKV
IRMWSHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9284.61 Da        Isoelectric Point: 4.2550

>AT249109 WP_066157209.1 NZ_CP099556:1060769-1061014 [Aliarcobacter cryaerophilus]
MTKVMTVSQVRADIYNIIDETALTHEPILITGKRTNAVMLSQEDWNAIQETLYLTSIPNMRESIIKGLNTSIEDCDKELE
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A494T483

Antitoxin

Source ID Structure
AlphaFold DB A0A1V9VC04

References