Detailed information of TA system TA024908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafN-yafO (relBE)/YafO-YafN
• Location: 3753238..3753932
• Replicon: chromosome
• Accession: NC_014500
• Organism: Dickeya dadantii 3937

Toxin (Protein)

• Gene name: yafO
• Uniprot ID: -
• Locus tag: DDA3937_RS16455
• Protein ID: WP_193345745.1
• Coordinates: 3753238..3753636 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: yafN
• Uniprot ID: E0SCS7
• Locus tag: DDA3937_RS16460
• Protein ID: WP_013319143.1
• Coordinates: 3753639..3753932 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDA3937_RS16440 (Dda3937_03195)	3749454..3750572	-	1119	WP_013319139.1	cytochrome c552	-
DDA3937_RS16445 (Dda3937_00956)	3750702..3751841	-	1140	WP_013319140.1	DltD	-
DDA3937_RS16450 (Dda3937_00955)	3752413..3752814	-	402	WP_033112396.1	hypothetical protein	-
DDA3937_RS16455 (Dda3937_00954)	3753238..3753636	-	399	WP_193345745.1	type II toxin-antitoxin system YafO family toxin	Toxin
DDA3937_RS16460 (Dda3937_00953)	3753639..3753932	-	294	WP_013319143.1	type I toxin-antitoxin system antitoxin YafN	Antitoxin
DDA3937_RS16465 (Dda3937_00952)	3754034..3754651	-	618	WP_033112022.1	hypothetical protein	-
DDA3937_RS23320 (Dda3937_00951)	3755024..3755284	-	261	WP_013319145.1	hypothetical protein	-
DDA3937_RS16470 (Dda3937_00950)	3755522..3756076	+	555	WP_052303361.1	hypothetical protein	-
DDA3937_RS16475 (Dda3937_00949)	3756119..3756805	-	687	WP_013319147.1	hypothetical protein	-
DDA3937_RS21690 (Dda3937_00948)	3756965..3757294	-	330	WP_015854059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3745037..3763374	18337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin YafO (27-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15259.50 Da
• Isoelectric Point: 7.0609

>T24908 WP_193345745.1 NC_014500:c3753636-3753238 [Dickeya dadantii 3937]
IRIFKSTLIRQQLSPQELDDLVADFLSYKKEGVLPDTFGRDAPYDDDRTYPLVKEEQVAHIHLADADAPFPKFLRQFKRT
SDQAHLVYCQGASDPDAYLLIIILKPEAHKMARNNNHMHKIGVMAEAFRMKY

Nucleotide

• Length: 399 bp

>T24908 NC_014500:c3753636-3753238 [Dickeya dadantii 3937]
ATCAGGATTTTCAAATCAACGCTTATCCGCCAGCAATTAAGCCCGCAAGAGCTGGATGATTTGGTGGCGGATTTTCTGTC
GTATAAAAAAGAGGGTGTGTTGCCGGATACCTTTGGCCGTGACGCCCCTTACGATGATGACCGCACCTATCCCCTGGTGA
AAGAAGAGCAAGTAGCGCACATTCATCTTGCCGATGCTGATGCCCCTTTTCCTAAGTTTTTACGCCAGTTCAAGCGAACC
AGCGATCAGGCCCACTTGGTGTACTGCCAGGGTGCCAGTGATCCAGATGCCTACCTGCTGATTATTATTCTGAAACCCGA
AGCGCATAAGATGGCGCGAAATAATAACCACATGCACAAGATAGGCGTGATGGCCGAAGCATTCAGAATGAAGTATTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11036.49 Da
• Isoelectric Point: 4.9062

>AT24908 WP_013319143.1 NC_014500:c3753932-3753639 [Dickeya dadantii 3937]
MERILAEKSINITELRKNPAKYFIDEPVAVLSNNRPAGYMVSAKVFEELIDLLEEKQGRVHTAARFRPSAERLSEITQNG
QTLLQNASDKDLTEFTE

Nucleotide

• Length: 294 bp

>AT24908 NC_014500:c3753932-3753639 [Dickeya dadantii 3937]
ATGGAGCGCATTCTTGCTGAAAAATCTATCAACATCACCGAGTTAAGAAAAAACCCGGCGAAATATTTTATTGATGAACC
TGTCGCGGTGCTCTCCAACAACCGCCCGGCTGGCTACATGGTCAGTGCCAAGGTGTTTGAAGAACTGATCGACCTGTTGG
AAGAGAAGCAGGGCAGGGTGCATACCGCTGCGCGTTTTCGTCCAAGCGCTGAAAGGTTAAGCGAGATTACGCAGAACGGG
CAGACACTGCTGCAAAACGCCTCTGACAAGGATCTGACCGAGTTCACGGAATGA

Structures

Antitoxin

• AlphaFold DB: E0SCS7