249053

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3639735..3640395 Replicon chromosome
Accession NZ_CP099513
Organism Klebsiella sp. ZYC-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NDO58_RS17125 Protein ID WP_154933529.1
Coordinates 3640042..3640395 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag NDO58_RS17120 Protein ID WP_004132739.1
Coordinates 3639735..3640037 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO58_RS17090 (NDO58_17060) 3634741..3636195 + 1455 WP_024359975.1 AMP nucleosidase -
NDO58_RS17100 (NDO58_17070) 3637223..3638680 - 1458 WP_004136541.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
NDO58_RS17110 (NDO58_17080) 3639004..3639337 - 334 Protein_3342 type II toxin-antitoxin system PemK/MazF family toxin -
NDO58_RS17115 (NDO58_17085) 3639338..3639541 - 204 Protein_3343 hypothetical protein -
NDO58_RS17120 (NDO58_17090) 3639735..3640037 - 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
NDO58_RS17125 (NDO58_17095) 3640042..3640395 - 354 WP_154933529.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDO58_RS17130 (NDO58_17100) 3640779..3642197 - 1419 WP_049085817.1 heavy metal sensor histidine kinase -
NDO58_RS17135 (NDO58_17105) 3642197..3642865 - 669 WP_004132733.1 heavy metal response regulator transcription factor -
NDO58_RS17140 (NDO58_17110) 3643005..3643631 + 627 WP_286453908.1 hypothetical protein -
NDO58_RS17145 (NDO58_17115) 3643646..3644254 + 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
NDO58_RS17150 (NDO58_17120) 3644244..3645011 + 768 WP_286453909.1 molybdopterin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13604.55 Da        Isoelectric Point: 9.5464

>T249053 WP_154933529.1 NZ_CP099513:c3640395-3640042 [Klebsiella sp. ZYC-1]
VWMIKTTDTFERWFTSFNDTDRASVLAALLVLREKGPGLSRPYADTLRGSRYSDMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT249053 WP_004132739.1 NZ_CP099513:c3640037-3639735 [Klebsiella sp. ZYC-1]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References