Detailed information of TA system TA249020

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2813377..2813956
• Replicon: chromosome
• Accession: NZ_CP099506
• Organism: Staphylococcus aureus strain 0316-H-5A

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: LPT22_RS13820
• Protein ID: WP_001025401.1
• Coordinates: 2813377..2813622 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2813591..2813956 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPT22_RS13785 (2809121)	2809121..2810326	-	1206	WP_031883891.1	tyrosine-type recombinase/integrase	-
LPT22_RS13790 (2810436)	2810436..2811059	+	624	WP_001166482.1	hypothetical protein	-
LPT22_RS13795 (2811257)	2811257..2811652	-	396	WP_000449655.1	hypothetical protein	-
LPT22_RS13800 (2811681)	2811681..2812115	-	435	WP_000755721.1	hypothetical protein	-
LPT22_RS13805 (2812133)	2812133..2812594	-	462	WP_031886309.1	toxin	-
LPT22_RS13810 (2812607)	2812607..2812936	-	330	WP_000429766.1	helix-turn-helix transcriptional regulator	-
LPT22_RS13815 (2813097)	2813097..2813288	+	192	WP_001115060.1	helix-turn-helix transcriptional regulator	-
LPT22_RS13820 (2813377)	2813377..2813622	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
LPT22_RS13825 (2813591)	2813591..2813956	-	366	WP_001128433.1	hypothetical protein	Antitoxin
LPT22_RS13830 (2814011)	2814011..2814226	+	216	WP_001036302.1	hypothetical protein	-
LPT22_RS13835 (2814251)	2814251..2814514	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
LPT22_RS13840 (2814527)	2814527..2814688	+	162	WP_001285963.1	DUF1270 family protein	-
LPT22_RS13845 (2814767)	2814767..2815090	+	324	WP_000175000.1	hypothetical protein	-
LPT22_RS13850 (2815105)	2815105..2815467	+	363	WP_000279445.1	hypothetical protein	-
LPT22_RS13855 (2815464)	2815464..2816630	+	1167	WP_000762532.1	DUF2800 domain-containing protein	-
LPT22_RS13860 (2816656)	2816656..2817213	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T249020 WP_001025401.1 NZ_CP099506:2813377-2813622 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT249020 NZ_CP099506:c2813956-2813591 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin