Detailed information of TA system TA249012

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG2-MW1433/-
• Location: 1567395..1567620
• Replicon: chromosome
• Accession: NZ_CP099506
• Organism: Staphylococcus aureus strain 0316-H-5A

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: LPT22_RS07715
• Protein ID: WP_000253687.1
• Coordinates: 1567513..1567620 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1567395..1567488 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPT22_RS07680 (1562899)	1562899..1563414	-	516	WP_000163283.1	type 1 glutamine amidotransferase domain-containing protein	-
LPT22_RS07685 (1563544)	1563544..1563705	-	162	WP_001005407.1	SE1561 family protein	-
LPT22_RS07690 (1564052)	1564052..1564132	+	81	WP_100250272.1	hypothetical protein	-
LPT22_RS07695 (1564862)	1564862..1565362	+	501	WP_113559807.1	hypothetical protein	-
LPT22_RS07700 (1565452)	1565452..1566897	-	1446	WP_031886331.1	SH3 domain-containing protein	-
LPT22_RS07705 (1566878)	1566878..1567315	-	438	WP_031886332.1	phage holin	-
LPT22_RS07710 (1567366)	1567366..1567473	+	108	Protein_1479	hypothetical protein	-
- (1567395)	1567395..1567488	+	94	NuclAT_0	-	Antitoxin
- (1567395)	1567395..1567488	+	94	NuclAT_0	-	Antitoxin
- (1567395)	1567395..1567488	+	94	NuclAT_0	-	Antitoxin
- (1567395)	1567395..1567488	+	94	NuclAT_0	-	Antitoxin
LPT22_RS07715 (1567513)	1567513..1567620	-	108	WP_000253687.1	putative holin-like toxin	Toxin
LPT22_RS07720 (1567857)	1567857..1568156	-	300	WP_031886333.1	DUF2951 domain-containing protein	-
LPT22_RS07725 (1568205)	1568205..1568354	-	150	WP_162783876.1	hypothetical protein	-
LPT22_RS07730 (1568341)	1568341..1570527	-	2187	WP_031886334.1	phage tail protein	-
LPT22_RS07735 (1570543)	1570543..1571658	-	1116	WP_031886335.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1562899..1601401	38502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3844.80 Da
• Isoelectric Point: 10.4997

>T249012 WP_000253687.1 NZ_CP099506:c1567620-1567513 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLNHKK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 94 bp

>AT249012 NZ_CP099506:1567395-1567488 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTTTTATATGAT
TAATAAATAACCAT

Structures

Antitoxin