Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1947628..1948145 Replicon chromosome
Accession NZ_CP099504
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag LPT20_RS09250 Protein ID WP_000113263.1
Coordinates 1947879..1948145 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag LPT20_RS09245 Protein ID WP_000584499.1
Coordinates 1947628..1947879 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT20_RS09215 (LPT20_09215) 1943328..1944047 + 720 WP_153155729.1 amino acid ABC transporter permease -
LPT20_RS09220 (LPT20_09220) 1944044..1944775 + 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
LPT20_RS09225 (LPT20_09225) 1944872..1946122 - 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
LPT20_RS09230 (LPT20_09230) 1946377..1946739 + 363 WP_000819839.1 DUF4467 domain-containing protein -
LPT20_RS09235 (LPT20_09235) 1946758..1947357 + 600 WP_000162810.1 DsbA family protein -
LPT20_RS09240 (LPT20_09240) 1947364..1947455 + 92 Protein_1824 hypothetical protein -
LPT20_RS09245 (LPT20_09245) 1947628..1947879 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LPT20_RS09250 (LPT20_09250) 1947879..1948145 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
LPT20_RS09255 (LPT20_09255) 1948180..1948251 + 72 WP_223200558.1 hypothetical protein -
LPT20_RS09260 (LPT20_09260) 1948439..1949986 + 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LPT20_RS09265 (LPT20_09265) 1950172..1950639 + 468 WP_000153338.1 SRPBCC domain-containing protein -
LPT20_RS09270 (LPT20_09270) 1950726..1950908 + 183 WP_000079140.1 hypothetical protein -
LPT20_RS09275 (LPT20_09275) 1951112..1951936 + 825 WP_000594633.1 formate/nitrite transporter family protein -
LPT20_RS09280 (LPT20_09280) 1952349..1952885 + 537 WP_000185901.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T249001 WP_000113263.1 NZ_CP099504:1947879-1948145 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT249001 WP_000584499.1 NZ_CP099504:1947628-1947879 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References