Detailed information of TA system TA248974

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2789812..2790391
• Replicon: chromosome
• Accession: NZ_CP099497
• Organism: Staphylococcus aureus strain 0213-M-4A

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: LPT21_RS13545
• Protein ID: WP_001025401.1
• Coordinates: 2789812..2790057 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2790026..2790391 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPT21_RS13510 (LPT21_13510)	2785556..2786761	-	1206	WP_031883891.1	tyrosine-type recombinase/integrase	-
LPT21_RS13515 (LPT21_13515)	2787144..2787494	+	351	WP_223200492.1	hypothetical protein	-
LPT21_RS13520 (LPT21_13520)	2787692..2788087	-	396	WP_000449655.1	hypothetical protein	-
LPT21_RS13525 (LPT21_13525)	2788116..2788550	-	435	WP_000755721.1	hypothetical protein	-
LPT21_RS13530 (LPT21_13530)	2788568..2789029	-	462	WP_031886309.1	toxin	-
LPT21_RS13535 (LPT21_13535)	2789042..2789371	-	330	WP_000429766.1	helix-turn-helix transcriptional regulator	-
LPT21_RS13540 (LPT21_13540)	2789532..2789723	+	192	WP_001115060.1	helix-turn-helix transcriptional regulator	-
LPT21_RS13545 (LPT21_13545)	2789812..2790057	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
LPT21_RS13550 (LPT21_13550)	2790026..2790391	-	366	WP_001128433.1	hypothetical protein	Antitoxin
LPT21_RS13555 (LPT21_13555)	2790446..2790661	+	216	WP_001036302.1	hypothetical protein	-
LPT21_RS13560 (LPT21_13560)	2790686..2790949	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
LPT21_RS13565 (LPT21_13565)	2790962..2791123	+	162	WP_001285963.1	DUF1270 family protein	-
LPT21_RS13570 (LPT21_13570)	2791202..2791525	+	324	WP_000175000.1	hypothetical protein	-
LPT21_RS13575 (LPT21_13575)	2791540..2791902	+	363	WP_000279445.1	hypothetical protein	-
LPT21_RS13580 (LPT21_13580)	2791899..2793065	+	1167	WP_000762532.1	DUF2800 domain-containing protein	-
LPT21_RS13585 (LPT21_13585)	2793091..2793648	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2785556..2806490	20934

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T248974 WP_001025401.1 NZ_CP099497:2789812-2790057 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT248974 NZ_CP099497:c2790391-2790026 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin