248957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 18813..19151 Replicon chromosome
Accession NZ_CP099495
Organism Staphylococcus aureus strain JL28

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag LPT16_RS00105 Protein ID WP_011447039.1
Coordinates 18813..18989 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 18977..19151 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT16_RS00085 14048..17833 + 3786 WP_096777926.1 phage tail spike protein -
LPT16_RS00090 17823..17975 + 153 WP_001153681.1 hypothetical protein -
LPT16_RS00095 18022..18309 + 288 WP_001040261.1 hypothetical protein -
LPT16_RS00100 18367..18663 + 297 WP_000539688.1 DUF2951 domain-containing protein -
LPT16_RS00105 18813..18989 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 18977..19151 - 175 - - Antitoxin
LPT16_RS00115 19201..19455 + 255 WP_000611512.1 phage holin -
LPT16_RS00120 19467..20222 + 756 WP_000861038.1 CHAP domain-containing protein -
LPT16_RS00125 20413..20904 + 492 WP_000919350.1 staphylokinase -
LPT16_RS00130 21554..21889 + 336 Protein_25 SH3 domain-containing protein -
LPT16_RS00135 21984..22433 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
LPT16_RS00140 23118..23468 + 351 WP_000702263.1 complement inhibitor SCIN-A -
LPT16_RS00145 23521..23781 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / chp / scn 1..23468 23467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T248957 WP_011447039.1 NZ_CP099495:18813-18989 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT248957 NZ_CP099495:c19151-18977 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References