248943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4543634..4544295 Replicon chromosome
Accession NZ_CP099489
Organism Ornithinimicrobium sp. HY1793

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag NF556_RS20985 Protein ID WP_252593291.1
Coordinates 4543945..4544295 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag NF556_RS20980 Protein ID WP_252593289.1
Coordinates 4543634..4543939 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF556_RS20955 (NF556_20955) 4539449..4540150 - 702 WP_252593279.1 4a-hydroxytetrahydrobiopterin dehydratase -
NF556_RS20960 (NF556_20960) 4540183..4540365 - 183 WP_252593280.1 hypothetical protein -
NF556_RS20965 (NF556_20965) 4540459..4541241 + 783 WP_252593283.1 class I SAM-dependent methyltransferase -
NF556_RS20970 (NF556_20970) 4541285..4542079 + 795 WP_252593284.1 VOC family protein -
NF556_RS20975 (NF556_20975) 4542827..4543252 + 426 WP_252593287.1 hypothetical protein -
NF556_RS20980 (NF556_20980) 4543634..4543939 - 306 WP_252593289.1 helix-turn-helix domain-containing protein Antitoxin
NF556_RS20985 (NF556_20985) 4543945..4544295 - 351 WP_252593291.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NF556_RS20990 (NF556_20990) 4545282..4545884 + 603 WP_252593293.1 hypothetical protein -
NF556_RS20995 (NF556_20995) 4545975..4546769 - 795 WP_252593295.1 class I SAM-dependent methyltransferase -
NF556_RS21000 (NF556_21000) 4547153..4547410 - 258 WP_252593297.1 hypothetical protein -
NF556_RS21005 (NF556_21005) 4547565..4547813 + 249 WP_252593299.1 hypothetical protein -
NF556_RS21010 (NF556_21010) 4547967..4548500 - 534 WP_252593301.1 GrpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13338.16 Da        Isoelectric Point: 5.7628

>T248943 WP_252593291.1 NZ_CP099489:c4544295-4543945 [Ornithinimicrobium sp. HY1793]
MWSVDIELIAEWLASLDQGSQEQVVAAMELLEDRGPQLGRPVVDTVSRSRHRNMKELRPGSSGRSELRILFAFDPERQAI
LLLAGDKAGNWQRWYKKNIPLADNLFDEHLRRLEGQ

Download         Length: 351 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11394.96 Da        Isoelectric Point: 7.2041

>AT248943 WP_252593289.1 NZ_CP099489:c4543939-4543634 [Ornithinimicrobium sp. HY1793]
MAKTISDFLAEHPVDREQVEKHKRRMLTEVRAYRLRELREEAGLTQAQLAERIGVGQRQVSKIESGDLDSAKIGTIRNYL
QAVGGDMAIEYVIGDNRVQVA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References