24888

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1713652..1714164 Replicon chromosome
Accession NC_014498
Organism Streptococcus pneumoniae 670-6B

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SP670_RS09110 Protein ID WP_000924721.1
Coordinates 1713652..1713906 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SP670_RS09115 Protein ID WP_000388572.1
Coordinates 1713910..1714164 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SP670_RS09095 1710753..1711067 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
SP670_RS09100 1711092..1711718 - 627 WP_000775037.1 guanylate kinase -
SP670_RS09105 1711848..1713461 - 1614 WP_000404940.1 ribonuclease Y -
SP670_RS09110 1713652..1713906 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SP670_RS09115 1713910..1714164 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SP670_RS09120 1714402..1715499 - 1098 WP_000156364.1 nucleotidyltransferase -
SP670_RS09125 1715509..1716255 - 747 WP_000605167.1 class I SAM-dependent methyltransferase -
SP670_RS09130 1716358..1716711 - 354 WP_001003001.1 ribosome silencing factor -
SP670_RS09135 1716724..1717224 - 501 WP_000844718.1 cysteine hydrolase -
SP670_RS09140 1717225..1717818 - 594 WP_000121660.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SP670_RS09145 1717818..1718447 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
SP670_RS09150 1718499..1718810 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T24888 WP_000924721.1 NC_014498:c1713906-1713652 [Streptococcus pneumoniae 670-6B]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T24888 NC_014498:c1713906-1713652 [Streptococcus pneumoniae 670-6B]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT24888 WP_000388572.1 NC_014498:c1714164-1713910 [Streptococcus pneumoniae 670-6B]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT24888 NC_014498:c1714164-1713910 [Streptococcus pneumoniae 670-6B]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References