Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2785170..2785692 Replicon chromosome
Accession NZ_CP099396
Organism Lacticaseibacillus rhamnosus strain P118

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag NFI97_RS12925 Protein ID WP_005687756.1
Coordinates 2785432..2785692 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag NFI97_RS12920 Protein ID WP_005687754.1
Coordinates 2785170..2785439 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFI97_RS12905 2780657..2782525 - 1869 WP_014571687.1 HTH domain-containing protein -
NFI97_RS12910 2782552..2783352 - 801 WP_005690776.1 SDR family oxidoreductase -
NFI97_RS12915 2783958..2784974 - 1017 WP_019728331.1 IS30 family transposase -
NFI97_RS12920 2785170..2785439 + 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NFI97_RS12925 2785432..2785692 + 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
NFI97_RS12930 2785903..2786631 - 729 WP_014571689.1 L-ribulose-5-phosphate 4-epimerase -
NFI97_RS12935 2786828..2787649 + 822 WP_005690770.1 Cof-type HAD-IIB family hydrolase -
NFI97_RS12940 2787716..2788603 - 888 WP_014571690.1 L-ribulose-5-phosphate 3-epimerase -
NFI97_RS12945 2788788..2789567 - 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
NFI97_RS12950 2789635..2790276 - 642 WP_005690763.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T248873 WP_005687756.1 NZ_CP099396:2785432-2785692 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT248873 WP_005687754.1 NZ_CP099396:2785170-2785439 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References