248843

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 43317..43966 Replicon chromosome
Accession NZ_CP099389
Organism Citrobacter braakii strain RHB02-E4-C01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFJ24_RS00200 Protein ID WP_235116967.1
Coordinates 43317..43658 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7L6TWH1
Locus tag NFJ24_RS00205 Protein ID WP_016157799.1
Coordinates 43667..43966 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ24_RS00185 (39753) 39753..41081 + 1329 WP_016155042.1 MFS transporter -
NFJ24_RS00190 (41224) 41224..42615 + 1392 WP_003023929.1 hexose-6-phosphate:phosphate antiporter -
NFJ24_RS00195 (42764) 42764..43216 + 453 WP_016157801.1 DUF1198 family protein -
NFJ24_RS00200 (43317) 43317..43658 + 342 WP_235116967.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ24_RS00205 (43667) 43667..43966 + 300 WP_016157799.1 helix-turn-helix transcriptional regulator Antitoxin
NFJ24_RS00210 (44085) 44085..45269 + 1185 WP_094169436.1 purine ribonucleoside efflux pump NepI -
NFJ24_RS00215 (45325) 45325..46707 - 1383 WP_016157797.1 glycoside hydrolase family 1 protein -
NFJ24_RS00220 (46800) 46800..47093 - 294 WP_019078023.1 YicS family protein -
NFJ24_RS00225 (47224) 47224..47640 + 417 WP_016155037.1 GNAT family N-acetyltransferase -
NFJ24_RS00230 (47812) 47812..48630 + 819 WP_046276188.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13060.97 Da        Isoelectric Point: 5.6550

>T248843 WP_235116967.1 NZ_CP099389:43317-43658 [Citrobacter braakii]
MWEVETTDVFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVIASAFSNMKELRVQHQGNPIRAFFVFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLNK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10988.84 Da        Isoelectric Point: 8.6007

>AT248843 WP_016157799.1 NZ_CP099389:43667-43966 [Citrobacter braakii]
MATLKELMAKQSPESQERIAEKVEVLRQVIALNMLREELNLSQAELASAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6TWH1

References