Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1653179..1653691 Replicon chromosome
Accession NC_014494
Organism Streptococcus pneumoniae AP200

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SPAP_RS08655 Protein ID WP_000924721.1
Coordinates 1653179..1653433 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B7LSG7
Locus tag SPAP_RS08660 Protein ID WP_000388571.1
Coordinates 1653437..1653691 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPAP_RS08640 1650280..1650594 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
SPAP_RS08645 1650619..1651245 - 627 WP_000775037.1 guanylate kinase -
SPAP_RS08650 1651375..1652988 - 1614 WP_000404940.1 ribonuclease Y -
SPAP_RS08655 1653179..1653433 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SPAP_RS08660 1653437..1653691 - 255 WP_000388571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SPAP_RS08665 1653929..1655026 - 1098 WP_000156345.1 nucleotidyltransferase -
SPAP_RS08670 1655036..1655782 - 747 WP_000605154.1 class I SAM-dependent methyltransferase -
SPAP_RS08675 1655885..1656238 - 354 WP_001003001.1 ribosome silencing factor -
SPAP_RS08680 1656251..1656751 - 501 WP_000844707.1 cysteine hydrolase -
SPAP_RS08685 1656752..1657345 - 594 WP_000121654.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SPAP_RS08690 1657345..1657974 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
SPAP_RS08695 1658026..1658337 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T24883 WP_000924721.1 NC_014494:c1653433-1653179 [Streptococcus pneumoniae AP200]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T24883 NC_014494:c1653433-1653179 [Streptococcus pneumoniae AP200]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9718.05 Da        Isoelectric Point: 4.8430

>AT24883 WP_000388571.1 NC_014494:c1653691-1653437 [Streptococcus pneumoniae AP200]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSIQVH
VIEE

Download         Length: 255 bp

>AT24883 NC_014494:c1653691-1653437 [Streptococcus pneumoniae AP200]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCTCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCATTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7LSG7

References