Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1943979..1944639 Replicon chromosome
Accession NZ_CP099376
Organism Citrobacter braakii strain RHB23-SO-C04

Toxin (Protein)


Gene name higB Uniprot ID A0A2I8S535
Locus tag NFK21_RS09170 Protein ID WP_053390179.1
Coordinates 1944286..1944639 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFK21_RS09165 Protein ID WP_053390178.1
Coordinates 1943979..1944281 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK21_RS09155 (1940499) 1940499..1941761 + 1263 WP_181545753.1 integrase arm-type DNA-binding domain-containing protein -
NFK21_RS09160 (1942593) 1942593..1943480 - 888 WP_103283719.1 integrase domain-containing protein -
NFK21_RS09165 (1943979) 1943979..1944281 - 303 WP_053390178.1 XRE family transcriptional regulator Antitoxin
NFK21_RS09170 (1944286) 1944286..1944639 - 354 WP_053390179.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK21_RS09175 (1945138) 1945138..1945359 - 222 WP_279266948.1 helix-turn-helix transcriptional regulator -
NFK21_RS09180 (1945356) 1945356..1945823 - 468 WP_200013604.1 hypothetical protein -
NFK21_RS09185 (1946189) 1946189..1948144 + 1956 WP_279266949.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13442.36 Da        Isoelectric Point: 9.0134

>T248719 WP_053390179.1 NZ_CP099376:c1944639-1944286 [Citrobacter braakii]
VWTIKTTDMFDHWFSSLNDIDRASVLAALLVLREKGPGLSRPYADTLRGSRFSNMKELRIQSRGDPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMIPVADREFTNWLNTIKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.86 Da        Isoelectric Point: 6.4738

>AT248719 WP_053390178.1 NZ_CP099376:c1944281-1943979 [Citrobacter braakii]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAKALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S535

Antitoxin

Source ID Structure

References