Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 979938..980665 Replicon chromosome
Accession NC_014391
Organism Micromonospora aurantiaca ATCC 27029

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag MICAU_RS04850 Protein ID WP_013284174.1
Coordinates 979938..980357 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MICAU_RS04855 Protein ID WP_013284175.1
Coordinates 980354..980665 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MICAU_RS04830 975500..976294 + 795 WP_047894511.1 ABC transporter permease -
MICAU_RS04835 976291..977712 + 1422 WP_013284171.1 FAD-binding oxidoreductase -
MICAU_RS04840 977712..978914 + 1203 WP_013284172.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
MICAU_RS04845 978911..979924 + 1014 WP_013284173.1 agmatinase -
MICAU_RS04850 979938..980357 + 420 WP_013284174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MICAU_RS04855 980354..980665 + 312 WP_013284175.1 helix-turn-helix transcriptional regulator Antitoxin
MICAU_RS04860 980685..981134 - 450 WP_013284176.1 hypothetical protein -
MICAU_RS04865 981236..981583 - 348 WP_013284177.1 DUF779 domain-containing protein -
MICAU_RS04870 981583..983088 - 1506 WP_013284178.1 aldehyde dehydrogenase family protein -
MICAU_RS04875 983129..984412 - 1284 WP_013284179.1 hypothetical protein -
MICAU_RS04880 984650..985315 + 666 WP_013284180.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(31-126)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-91)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15815.92 Da        Isoelectric Point: 10.7588

>T24871 WP_013284174.1 NC_014391:979938-980357 [Micromonospora aurantiaca ATCC 27029]
MFSPGYSRGMGADGKRWSVRVTGEVRHWLRDLRDHDPSSYESVRVAVDKLAEVGPGLGRPLVDTLRGSSLRNLKELRPRS
GRDVAIRVLFVFDPWSQAVLLVAGNKAGNWTRWYRQHIPAAEVAYKAWLDSERERRGES

Download         Length: 420 bp

>T24871 NC_014391:979938-980357 [Micromonospora aurantiaca ATCC 27029]
ATGTTTAGCCCGGGCTATAGTCGGGGCATGGGTGCGGACGGGAAGCGCTGGTCGGTGCGGGTCACCGGAGAGGTCCGGCA
CTGGCTGCGCGACCTGCGGGACCACGACCCGTCGTCGTACGAGAGCGTCCGGGTGGCGGTGGACAAGCTGGCCGAGGTCG
GGCCGGGGCTGGGTCGCCCGCTCGTGGACACGCTGCGTGGAAGCAGTCTCCGTAATCTGAAGGAGCTGCGGCCCCGCTCC
GGTCGGGACGTGGCTATCCGGGTGCTGTTCGTCTTCGATCCCTGGTCGCAGGCGGTCCTCCTGGTCGCCGGCAACAAGGC
GGGCAACTGGACCCGCTGGTACCGGCAGCACATTCCGGCGGCGGAGGTTGCCTACAAGGCTTGGCTCGACAGCGAGCGCG
AGCGAAGGGGGGAGTCGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11668.90 Da        Isoelectric Point: 4.3953

>AT24871 WP_013284175.1 NC_014391:980354-980665 [Micromonospora aurantiaca ATCC 27029]
VTEFYHWDEVRAELGGDDEAYEAERARTDAWVSAFHLAEERKRLGLTQRQVAEIMGVTPGRVSQIENGDLDVNEVATLSR
YANALGARLRIIFDYGDDLRQIA

Download         Length: 312 bp

>AT24871 NC_014391:980354-980665 [Micromonospora aurantiaca ATCC 27029]
GTGACGGAGTTCTATCACTGGGACGAGGTCCGCGCCGAACTCGGCGGTGACGACGAGGCGTACGAGGCGGAGCGCGCCCG
GACCGACGCGTGGGTGAGCGCGTTCCACCTGGCCGAGGAGCGCAAGCGGCTGGGGCTCACCCAGCGGCAGGTCGCCGAGA
TCATGGGGGTCACGCCGGGCCGGGTCAGCCAGATCGAGAACGGCGACCTCGACGTCAACGAGGTGGCCACGCTGAGCCGG
TACGCCAATGCCCTCGGCGCCCGGCTGCGGATCATCTTCGACTACGGCGACGACCTCCGGCAGATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References