Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 979938..980665 Replicon chromosome
Accession NC_014391
Organism Micromonospora aurantiaca ATCC 27029

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag MICAU_RS04850 Protein ID WP_013284174.1
Coordinates 979938..980357 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MICAU_RS04855 Protein ID WP_013284175.1
Coordinates 980354..980665 (+) Length 104 a.a.

Genomic Context

MICAU_RS04830MICAU_RS04835MICAU_RS04840MICAU_RS04845MICAU_RS04850MICAU_RS04855MICAU_RS04880MICAU_RS04860MICAU_RS04865MICAU_RS04870MICAU_RS04875
Location: 975500..976294 (795 bp)
Type: Others
Protein ID: WP_047894511.1
Location: 976291..977712 (1422 bp)
Type: Others
Protein ID: WP_013284171.1
Location: 977712..978914 (1203 bp)
Type: Others
Protein ID: WP_013284172.1
Location: 978911..979924 (1014 bp)
Type: Others
Protein ID: WP_013284173.1
Location: 979938..980357 (420 bp)
Type: Toxin
Protein ID: WP_013284174.1
Location: 980354..980665 (312 bp)
Type: Antitoxin
Protein ID: WP_013284175.1
Location: 984650..985315 (666 bp)
Type: Others
Protein ID: WP_013284180.1
Location: 980685..981134 (450 bp)
Type: Others
Protein ID: WP_013284176.1
Location: 981236..981583 (348 bp)
Type: Others
Protein ID: WP_013284177.1
Location: 981583..983088 (1506 bp)
Type: Others
Protein ID: WP_013284178.1
Location: 983129..984412 (1284 bp)
Type: Others
Protein ID: WP_013284179.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MICAU_RS04830975500..976294+795WP_047894511.1ABC transporter permease-
MICAU_RS04835976291..977712+1422WP_013284171.1FAD-binding oxidoreductase-
MICAU_RS04840977712..978914+1203WP_013284172.1saccharopine dehydrogenase NADP-binding domain-containing protein-
MICAU_RS04845978911..979924+1014WP_013284173.1agmatinase-
MICAU_RS04850979938..980357+420WP_013284174.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MICAU_RS04855980354..980665+312WP_013284175.1helix-turn-helix transcriptional regulatorAntitoxin
MICAU_RS04860980685..981134-450WP_013284176.1hypothetical protein-
MICAU_RS04865981236..981583-348WP_013284177.1DUF779 domain-containing protein-
MICAU_RS04870981583..983088-1506WP_013284178.1aldehyde dehydrogenase family protein-
MICAU_RS04875983129..984412-1284WP_013284179.1hypothetical protein-
MICAU_RS04880984650..985315+666WP_013284180.1response regulator transcription factor-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(31-126)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-91)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15815.92 Da        Isoelectric Point: 10.7588

>T24871 WP_013284174.1 NC_014391:979938-980357 [Micromonospora aurantiaca ATCC 27029]
MFSPGYSRGMGADGKRWSVRVTGEVRHWLRDLRDHDPSSYESVRVAVDKLAEVGPGLGRPLVDTLRGSSLRNLKELRPRS
GRDVAIRVLFVFDPWSQAVLLVAGNKAGNWTRWYRQHIPAAEVAYKAWLDSERERRGES

Download         Length: 420 bp

>T24871 NC_014391:979938-980357 [Micromonospora aurantiaca ATCC 27029]
ATGTTTAGCCCGGGCTATAGTCGGGGCATGGGTGCGGACGGGAAGCGCTGGTCGGTGCGGGTCACCGGAGAGGTCCGGCA
CTGGCTGCGCGACCTGCGGGACCACGACCCGTCGTCGTACGAGAGCGTCCGGGTGGCGGTGGACAAGCTGGCCGAGGTCG
GGCCGGGGCTGGGTCGCCCGCTCGTGGACACGCTGCGTGGAAGCAGTCTCCGTAATCTGAAGGAGCTGCGGCCCCGCTCC
GGTCGGGACGTGGCTATCCGGGTGCTGTTCGTCTTCGATCCCTGGTCGCAGGCGGTCCTCCTGGTCGCCGGCAACAAGGC
GGGCAACTGGACCCGCTGGTACCGGCAGCACATTCCGGCGGCGGAGGTTGCCTACAAGGCTTGGCTCGACAGCGAGCGCG
AGCGAAGGGGGGAGTCGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11668.90 Da        Isoelectric Point: 4.3953

>AT24871 WP_013284175.1 NC_014391:980354-980665 [Micromonospora aurantiaca ATCC 27029]
VTEFYHWDEVRAELGGDDEAYEAERARTDAWVSAFHLAEERKRLGLTQRQVAEIMGVTPGRVSQIENGDLDVNEVATLSR
YANALGARLRIIFDYGDDLRQIA

Download         Length: 312 bp

>AT24871 NC_014391:980354-980665 [Micromonospora aurantiaca ATCC 27029]
GTGACGGAGTTCTATCACTGGGACGAGGTCCGCGCCGAACTCGGCGGTGACGACGAGGCGTACGAGGCGGAGCGCGCCCG
GACCGACGCGTGGGTGAGCGCGTTCCACCTGGCCGAGGAGCGCAAGCGGCTGGGGCTCACCCAGCGGCAGGTCGCCGAGA
TCATGGGGGTCACGCCGGGCCGGGTCAGCCAGATCGAGAACGGCGACCTCGACGTCAACGAGGTGGCCACGCTGAGCCGG
TACGCCAATGCCCTCGGCGCCCGGCTGCGGATCATCTTCGACTACGGCGACGACCTCCGGCAGATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References