Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-couple_hipB
Location 897980..898656 Replicon chromosome
Accession NC_014391
Organism Micromonospora aurantiaca ATCC 27029

Toxin (Protein)


Gene name higB Uniprot ID D9TB09
Locus tag MICAU_RS04490 Protein ID WP_013284103.1
Coordinates 898294..898656 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MICAU_RS04485 Protein ID WP_013284102.1
Coordinates 897980..898297 (-) Length 106 a.a.

Genomic Context

MICAU_RS04445MICAU_RS04450MICAU_RS04455MICAU_RS04460MICAU_RS04470MICAU_RS04475MICAU_RS04480MICAU_RS04495MICAU_RS04500MICAU_RS04505MICAU_RS04510MICAU_RS04515MICAU_RS04465MICAU_RS04485MICAU_RS04490
Location: 893170..893805 (636 bp)
Type: Others
Protein ID: WP_013284094.1
Location: 893829..894386 (558 bp)
Type: Others
Protein ID: WP_013284095.1
Location: 894388..894897 (510 bp)
Type: Others
Protein ID: WP_013284096.1
Location: 894940..895869 (930 bp)
Type: Others
Protein ID: WP_013284097.1
Location: 896252..896539 (288 bp)
Type: Others
Protein ID: WP_013284099.1
Location: 896603..896935 (333 bp)
Type: Others
Protein ID: WP_041798804.1
Location: 896932..897897 (966 bp)
Type: Others
Protein ID: WP_013284101.1
Location: 898834..899601 (768 bp)
Type: Others
Protein ID: WP_013284104.1
Location: 899621..900334 (714 bp)
Type: Others
Protein ID: WP_013284105.1
Location: 900355..901086 (732 bp)
Type: Others
Protein ID: WP_013284106.1
Location: 901083..901667 (585 bp)
Type: Others
Protein ID: WP_013284107.1
Location: 901667..902665 (999 bp)
Type: Others
Protein ID: WP_013284108.1
Location: 895972..896151 (180 bp)
Type: Others
Protein ID: WP_013284098.1
Location: 897980..898297 (318 bp)
Type: Antitoxin
Protein ID: WP_013284102.1
Location: 898294..898656 (363 bp)
Type: Toxin
Protein ID: WP_013284103.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MICAU_RS04445893170..893805+636WP_013284094.1septum formation initiator family protein-
MICAU_RS04450893829..894386+558WP_013284095.1DUF501 domain-containing protein-
MICAU_RS04455894388..894897+510WP_013284096.1amino-acid N-acetyltransferase-
MICAU_RS04460894940..895869+930WP_013284097.1Ppx/GppA family phosphatase-
MICAU_RS04465895972..896151-180WP_013284098.1hypothetical protein-
MICAU_RS04470896252..896539+288WP_013284099.1hypothetical protein-
MICAU_RS04475896603..896935+333WP_041798804.1PadR family transcriptional regulator-
MICAU_RS04480896932..897897+966WP_013284101.1hypothetical protein-
MICAU_RS04485897980..898297-318WP_013284102.1helix-turn-helix domain-containing proteinAntitoxin
MICAU_RS04490898294..898656-363WP_013284103.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MICAU_RS04495898834..899601+768WP_013284104.1dienelactone hydrolase family protein-
MICAU_RS04500899621..900334+714WP_013284105.1uracil-DNA glycosylase-
MICAU_RS04505900355..901086+732WP_013284106.1DUF4129 domain-containing protein-
MICAU_RS04510901083..901667+585WP_013284107.1hypothetical protein-
MICAU_RS04515901667..902665+999WP_013284108.1MoxR family ATPase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13551.40 Da        Isoelectric Point: 6.0857

>T24870 WP_013284103.1 NC_014391:c898656-898294 [Micromonospora aurantiaca ATCC 27029]
VVAGDWDVYLVDEVRQWLDTLDASAHARVVQAIDLLAEHGPGLGRPLVDTIHGSSMANLKELRPGTVRILFAFDPWRSSI
LLVAGDKSGRWKTWYQEAIPVAEHRYELYLKDRAREEGKA

Download         Length: 363 bp

>T24870 NC_014391:c898656-898294 [Micromonospora aurantiaca ATCC 27029]
GTGGTGGCTGGAGACTGGGACGTCTACCTGGTCGACGAGGTGCGGCAGTGGCTCGACACTCTCGACGCGTCCGCCCATGC
GCGAGTGGTGCAGGCGATCGACCTCCTGGCCGAGCACGGACCAGGACTCGGACGACCCCTTGTCGACACCATCCACGGTT
CGTCGATGGCGAACTTGAAGGAGCTCCGGCCGGGCACCGTGCGTATCCTTTTCGCGTTCGACCCGTGGCGCTCGAGCATC
CTCCTGGTCGCCGGCGACAAGTCCGGCCGGTGGAAGACGTGGTATCAGGAGGCCATTCCCGTCGCCGAGCACCGCTACGA
GCTCTACCTCAAGGACCGGGCACGAGAGGAGGGGAAGGCATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11399.80 Da        Isoelectric Point: 6.7267

>AT24870 WP_013284102.1 NC_014391:c898297-897980 [Micromonospora aurantiaca ATCC 27029]
MSDYSRWQDIRADHVARVGGEDAVDAGKQELLAEVIGHRLAEVRRARGLTQQQVADRMGVTKGRVSQIEQGKISGQEVVA
RFAAALGGRLHQAIYFDDGDIAAIA

Download         Length: 318 bp

>AT24870 NC_014391:c898297-897980 [Micromonospora aurantiaca ATCC 27029]
ATGAGCGACTACTCCCGGTGGCAGGACATCCGCGCCGACCACGTCGCCCGGGTCGGCGGGGAAGATGCGGTCGACGCGGG
TAAGCAGGAACTCCTCGCCGAGGTCATCGGTCACCGCCTCGCGGAGGTACGGCGAGCGCGCGGCCTGACCCAGCAGCAGG
TCGCCGACCGGATGGGCGTCACCAAGGGACGGGTCTCCCAGATCGAGCAGGGAAAGATCTCCGGACAGGAAGTGGTGGCC
CGGTTCGCCGCGGCGCTGGGTGGCCGGCTCCACCAGGCGATCTACTTCGACGACGGTGACATCGCCGCCATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD9TB09

Antitoxin

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Source
ID
Structure
No matching records found

References