248689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5070243..5070842 Replicon chromosome
Accession NZ_CP099373
Organism Citrobacter portucalensis strain RHB38-SO-C05

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFK58_RS24370 Protein ID WP_079939298.1
Coordinates 5070531..5070842 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NFK58_RS24365 Protein ID WP_079939299.1
Coordinates 5070243..5070530 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK58_RS24350 (NFK58_24370) 5067739..5068641 + 903 WP_042313505.1 formate dehydrogenase O subunit beta -
NFK58_RS24355 (NFK58_24375) 5068638..5069273 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
NFK58_RS24360 (NFK58_24380) 5069270..5070199 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
NFK58_RS24365 (NFK58_24385) 5070243..5070530 - 288 WP_079939299.1 NadS family protein Antitoxin
NFK58_RS24370 (NFK58_24390) 5070531..5070842 - 312 WP_079939298.1 toxin HigB-2 Toxin
NFK58_RS24375 (NFK58_24395) 5071062..5071970 + 909 WP_191227953.1 alpha/beta hydrolase -
NFK58_RS24380 (NFK58_24400) 5072035..5072277 + 243 WP_003825282.1 type II toxin-antitoxin system ParD family antitoxin -
NFK58_RS24385 (NFK58_24405) 5072270..5072626 + 357 WP_249418773.1 type II toxin-antitoxin system RelE/ParE family toxin -
NFK58_RS24390 (NFK58_24410) 5072563..5073504 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
NFK58_RS24395 (NFK58_24415) 5073549..5073986 - 438 WP_003825289.1 D-aminoacyl-tRNA deacylase -
NFK58_RS24400 (NFK58_24420) 5073983..5074855 - 873 WP_079939294.1 virulence factor BrkB family protein -
NFK58_RS24405 (NFK58_24425) 5074849..5075448 - 600 WP_123269190.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12261.38 Da        Isoelectric Point: 10.0972

>T248689 WP_079939298.1 NZ_CP099373:c5070842-5070531 [Citrobacter portucalensis]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQDTGGLRKVRWRARGKGKRSGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNEGW

Download         Length: 312 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10775.39 Da        Isoelectric Point: 11.1842

>AT248689 WP_079939299.1 NZ_CP099373:c5070530-5070243 [Citrobacter portucalensis]
MDKALFERLTQSMIQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References