Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4696450..4697114 Replicon chromosome
Accession NZ_CP099370
Organism Citrobacter portucalensis strain RHB40-E3-C01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NFK62_RS23165 Protein ID WP_032942116.1
Coordinates 4696812..4697114 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5A9BY49
Locus tag NFK62_RS23160 Protein ID WP_008786950.1
Coordinates 4696450..4696791 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK62_RS23130 (4691807) 4691807..4692565 + 759 WP_279275277.1 phosphonate C-P lyase system protein PhnK -
NFK62_RS23135 (4692833) 4692833..4693519 + 687 WP_279275278.1 phosphonate C-P lyase system protein PhnL -
NFK62_RS23140 (4693516) 4693516..4694652 + 1137 WP_126319496.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
NFK62_RS23145 (4694655) 4694655..4695209 + 555 WP_279275279.1 ribose 1,5-bisphosphokinase -
NFK62_RS23150 (4695196) 4695196..4695630 + 435 WP_126319498.1 aminoalkylphosphonate N-acetyltransferase -
NFK62_RS23155 (4695639) 4695639..4696397 + 759 WP_148362557.1 phosphonate metabolism protein PhnP -
NFK62_RS23160 (4696450) 4696450..4696791 - 342 WP_008786950.1 HigA family addiction module antitoxin Antitoxin
NFK62_RS23165 (4696812) 4696812..4697114 - 303 WP_032942116.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK62_RS23170 (4697270) 4697270..4697599 - 330 WP_003031807.1 DDRRRQL repeat protein YjdP -
NFK62_RS23175 (4697669) 4697669..4699933 - 2265 WP_279275280.1 hybrid sensor histidine kinase/response regulator -
NFK62_RS23180 (4700048) 4700048..4701571 + 1524 WP_149281896.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-98)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11860.49 Da        Isoelectric Point: 9.9581

>T248673 WP_032942116.1 NZ_CP099370:c4697114-4696812 [Citrobacter portucalensis]
MSKSLNIRNFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWINGKAEDVYLDPHIY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12986.83 Da        Isoelectric Point: 6.4743

>AT248673 WP_008786950.1 NZ_CP099370:c4696791-4696450 [Citrobacter portucalensis]
MKQASRKPTTVGDILQYEYLEPLDLKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRDVGAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5A9BY49

References