Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 46726..47996 Replicon chromosome
Accession NC_014371
Organism Prevotella melaninogenica ATCC 25845

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag HMPREF0659_RS07305 Protein ID WP_013265740.1
Coordinates 46726..47661 (-) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag HMPREF0659_RS07310 Protein ID WP_013265071.1
Coordinates 47661..47996 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0659_RS07290 42225..42743 + 519 WP_013265649.1 histidine phosphatase family protein -
HMPREF0659_RS07295 43017..43886 - 870 WP_013265448.1 hypothetical protein -
HMPREF0659_RS12755 44665..44826 + 162 WP_167310037.1 hypothetical protein -
HMPREF0659_RS07300 44852..46438 + 1587 WP_013265909.1 fimbrillin family protein -
HMPREF0659_RS07305 46726..47661 - 936 WP_013265740.1 HipA domain-containing protein Toxin
HMPREF0659_RS07310 47661..47996 - 336 WP_013265071.1 HipA N-terminal domain-containing protein Antitoxin
HMPREF0659_RS07315 47993..48196 - 204 WP_013265868.1 helix-turn-helix transcriptional regulator -
HMPREF0659_RS07320 48886..50481 + 1596 WP_044046165.1 hypothetical protein -
HMPREF0659_RS07325 50515..50964 + 450 WP_013265542.1 lipocalin-like domain-containing protein -
HMPREF0659_RS07330 51298..52404 - 1107 WP_044046024.1 undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(54-278)

Antitoxin

HipA, N-terminal subdomain 1

(3-101)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35897.58 Da        Isoelectric Point: 8.2694

>T24865 WP_013265740.1 NC_014371:c47661-46726 [Prevotella melaninogenica ATCC 25845]
MCKCLYCYQKLEEGQKDFHPHCARKFFGTKDVPLLEYKHKDLEELAEQVIRAQTSLTGVQPKLSLNLNKHDGCNRLTIVG
LWGDYIFKPQTEAYSQLPENEDLTMHLAEAAKIKVVPHSLIRLSDGKLGYLTKRIDRTKNGEKIDMEDMCQLTLHPTEYK
YKGSYEQIAKTITQYSSTPKLDLTNYMQLLLFCFITGNNDMHLKNFSLYRPSKDYQLAPAYDLLNTTIANPKDKEELAMP
LSGRKSKLCLDDFLNTAKTIGLEENIVLRLVKGFEKALPKWKLLIESSFLDEDMKKEYNKLIVSRLNRLQG

Download         Length: 936 bp

>T24865 NC_014371:c47661-46726 [Prevotella melaninogenica ATCC 25845]
ATGTGTAAATGTCTGTATTGCTATCAAAAATTGGAAGAGGGTCAGAAAGACTTTCATCCTCATTGTGCTCGCAAGTTCTT
TGGTACAAAAGATGTTCCCTTATTGGAATATAAACATAAAGACCTCGAAGAATTAGCCGAACAAGTAATCCGCGCCCAGA
CATCGCTGACAGGAGTTCAGCCTAAATTGTCTCTAAACCTCAATAAACACGATGGTTGTAACCGATTAACCATTGTCGGA
CTTTGGGGGGATTATATCTTTAAACCACAGACAGAGGCTTACTCACAGCTGCCTGAAAATGAGGACTTAACAATGCACCT
TGCAGAAGCTGCAAAGATAAAAGTCGTACCACATAGCTTAATTCGTTTGTCTGATGGGAAGTTGGGGTATCTCACCAAGC
GTATTGATCGTACCAAGAATGGTGAGAAAATAGATATGGAGGATATGTGTCAGTTAACGTTACACCCTACAGAATATAAG
TATAAAGGATCGTACGAGCAGATAGCAAAAACGATAACACAATATAGTAGTACACCCAAACTCGACTTAACCAACTATAT
GCAATTATTGCTTTTCTGCTTTATCACTGGTAACAACGACATGCATCTGAAGAACTTCTCTCTTTATCGTCCTTCAAAAG
ATTATCAATTAGCTCCAGCTTATGACCTTCTCAACACTACGATAGCAAATCCTAAAGACAAAGAGGAATTGGCAATGCCG
CTCTCTGGACGAAAATCGAAGCTGTGTCTTGATGACTTCTTAAACACTGCAAAGACAATAGGCTTAGAAGAAAACATTGT
ATTGCGCCTCGTAAAAGGTTTTGAAAAGGCTCTCCCTAAATGGAAGTTGCTCATAGAGAGTTCATTTCTTGACGAAGATA
TGAAAAAGGAATATAATAAACTTATCGTATCCCGATTGAATCGTTTGCAAGGATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12583.68 Da        Isoelectric Point: 4.3774

>AT24865 WP_013265071.1 NC_014371:c47996-47661 [Prevotella melaninogenica ATCC 25845]
MRQAEIYRKRILAGILTEDGGEYRFCYDEKYLVQEDAQPISLTFPLQTEPFVSPVLFPFFDGLIPEGWLLDVALRNTNIS
VLDRMSLLLLCCKECIGAVSIIPRKELGGDV

Download         Length: 336 bp

>AT24865 NC_014371:c47996-47661 [Prevotella melaninogenica ATCC 25845]
ATGAGACAAGCAGAAATATATCGAAAGAGAATTCTCGCTGGTATTCTGACAGAAGATGGTGGCGAATACCGATTCTGTTA
TGACGAGAAGTATCTTGTACAGGAAGATGCCCAACCTATAAGTTTGACATTCCCATTACAGACGGAACCGTTTGTAAGTC
CTGTGTTATTCCCATTTTTTGATGGGCTAATACCCGAAGGATGGTTGCTTGATGTGGCACTTCGCAATACCAACATCAGC
GTTCTTGACCGTATGTCGTTATTACTATTATGCTGTAAGGAGTGTATAGGCGCTGTAAGTATTATTCCACGGAAAGAATT
AGGAGGTGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References